The American Society for 

Reproductive Immunology 

WEdnesday, June 27

14:00-20:00 PM   Registration

Thursday, June 28 - CLINICAL SYMPOSIUM*

7:30 AM-20:00 Registration                                                                                                                             *PPT in English; Talks in Chinese

Management of Reproductive Immunology and Its New Strategy

08:15-08:30   Welcome Address - MeiRong Du & DaJin Li 

08:30-10:00 CS1: Recurrent Spontaneous Abortion I

Chairs: Li-Ping Jin, Wen-Hui Zhou

CL1 The Study of Reproductive Immunology - DaJin Li, FuDan University

CL2 Anticoagulant Therapy of RSA - AiMin Zhao, Renji Hospital, Shanghai JiaoTong University

CL3 The Immunology of PCOS - Wei Zhang, FuDan University

10:00-10:20   Coffee Break

10:20-11:50  CS2: Recurrent Spontaneous Abortion II

CL4 Diagnosis and Treatment of Immunological Infertility - Jian-Ping Zhang, Zhanshan University

CL5 Precision prevention of pregnancy failure in RSA patients - JiangMing Chen, Guangzhou Army Police Hospital

CL6 Research progress on Peri-menopausal diseases and immunology - Ling Wang, FuDan University

12:00-1:00 Lunch Break

13:00-15:00  CS3: Repeated Implantation Failures I

Chairs: Yu Huang, Rui Zhu

CL7 The Application of CsA in IVF-ET - YuanHua Huang, HaiNan Medical University

CL8 The correlation between surveillance of drug-related genetic polymorphism and clinical outcomes in immunotherapy - Jing Tang, FuDan University

CL9 The application of assessment of endometrial receptivity in recurrent miscarriage and repeated implantation failure - Chun-Yu Huang, Shenzhen Zhongshan Urology Hospital

CL10 Nature Killer cells in recurrent pregnancy loss - from peripheral blood to uterus - Qiong Wang, Zhongshan University

CL11 Standard of diagnosis and treatment of RSA - Li-Ping Jing, The First Maternal-Infant Hospital, TongJi University

15:00-15:10 Coffee Break

15:10-16:10 CS4: Repeated Implantation Failures I

CL12 Repeated implantation failure: Therapeutic effects of intrauterine administration of PBMCs - Jing Yang, WuHan Univ.

CL13 New consensus for diagnosis and treatment of POI in China - Jie Wu, Nanjing Medical University

16:20  Adjourn

Thursday, June 28 - Annual Meeting

ASRI-CSI Joint Congress Opening

16:45-17:00 Welcome and Announcements

Meeting Chairs’ Greeting - Dr. DaJin Li     President of ASRI - Dr. Nazeeh Hanna

17:00-18:00     KN: Keynote Address: Natural killer cells and vascular remodeling at the maternal fetal


Sumati Rajagopalan, National Institute of Allergy and Infectious Diseases

18:30-20:30 Reception & Dinner

Friday, June 29 - ANNUAL MEETING

7:30-12:00 Registration

08:00-08:30   Opening Ceremony - MeiRong Du & Nazeeh Hanna

08:30-10:00 S1: Presidential Session    

Chairs: DaJin Li, Nazeeh Hanna

  1. Dietary and Environmental Influences on the Epigenetic Regulation of Placental Genes - Sherin Devaskar, UCLA Health
  2. Preventing Prematurity: New Insights from GenomicsLouis Muglia, Cincinnati Children’s Hospital Medical Center

10:00-10:20 Coffee Break

10:20-12:00 S2: John Gusdon Award Competition Presentations 

Chair: Andreas Meinhardi

          1. Pyroptosis: a novel mechanism for release of alarmins in the pathogenesis of preeclampsia - Shi-Bing Cheng, Brown University
          2. Prognostic value of the measurement of CD8+T cells in the endometrium of women with repeated implantation failure - Yu-Ye Li, Shenzhen ZhongShan Urology Hospital
          3. Expression of IL-36 cytokine family in trophoblastic cells - Jose Martin Murrieta Coxca, National School of Biological Sciences-IPN, Mexico

          4. The activation of Tim-3/Gal-9 pathway can alleviate the preeclampsia-like manifestations induced by LPS in rats by regulating the polarization of decidual macrophages - Li-Ling Wang, Huazhong University of Science and Technology

          5. Clonally expanded decidual effector Treg cells increase in late gestation of normal pregnancy, but not in preeclampsia in human - Sayaka Tsuda, University of Toyama, Japan
          6. Estrogen-autophagy-NK cells” regulatory axis in endometrium immune homeostasis and endometriosis - Ming-Qing Li, FuDan University

12:00-12:30 Satellite Conference: The position of dydrogesterone in the treatment of recurrent abortion

Sponsored by Abbott Company, China

12:00-1:00    Lunch Break

1:00-3:00 S3: Frontier Progress in Immunology

Chairs: Ji-Yang Wang, Charu Kaushic

  1. Control of T cells in inflammation and cancer - Chen Dong, Tsinghua University
  2. Yin and Yang Regulation of GC Reaction - YuZang Wu, Army Medical University

  3. ECM1 controls Th2 migration and promotes differentiation of follicular helper T cells by antagonizing IL-2-STAT5 pathway - Bing Sun, Chinese Academy of Science

  4. Getting Rid of Old Thoughts: The New Facets of the Testicular Immune System - Andreas Meinhardt, University of Giessen

    3:00-3:15 Coffee Break

    3:15-4:30  S4: Award Lectures Chairs: Gil Mor, Jeffrey Braverman

              1. State of the Art of AJRI & Introduction to AJRI Award - Gil Mor
              2. AJRI Award Lecture: Sex hormone-microbiome-immunity axis and HIV-1 Susceptibility in Female Genital Tract - Charu Kaushic
              3. Introduction to the Braverman Award - Nadera Mansouri-Attia
              4. Braverman Award Lecture: miRNAs, New Players in the Endotoxin Tolerance Game - Caterina Tiozzo, NYU Winthrop Hospital

      6:00-8:30  Welcome Dinner with Entertainment

      Saturday, June 30 - ANNUAL MEETING

      8:00-8:30   Morning Announcements

      8:30 - 10:00 BREAKOUT SESSIONS:

      B1: Novel Aspects of Maternal-Fetal Immune Regulation I  

      Chairs: Yan-Ling Wang, Shigeru Saito

      1. Interactions between placental trophoblast cells and maternal immune cells at the feto-maternal interface

        - Yan-Ling Wang, Chinese Academy of Science
      2. Pathophysiology of preterm labor from the viewpoints of infection and inflammation - Shigeru Saito, University of Toyama, Japan
      3. Miscarriage induced by activated innate immune cells in mice - Yakasuki Negishi, Nihon Medical University
      4. Functional regulation of Tim-3 on decidual macrophages during early pregnancy - Song-Cun Wang, FuDan University

      5. Role of TAM receptors on decidual macrophage polarization and capacity for tissue repair - Paulomi Aldo, Yale University, USA

      B2: Reproductive Endocrine-Metabolo-Immunology Networks I    

      Chairs: DaJin Li, Gil Mor

      1. Inflammation and implantation: an evolutionary need for the success of pregnancy - Gil Mor, Yale University
      2. Immune cells and endometriotic lesions: Partners in crime in inflicting pains in women with endometriosis - Sun-Wei Guo, FuDan University, China

      3. Insulin resistance adversely affects IVF outcome in women with infertility: A possible role of B cell immunity? - Hao-Yu Wang, Anhui Medical University

      4. Natural cytotoxicity receptors expression and cytokines production of natural killer cells in patients with endometriosis - Ayano Yamaya, Hirosaki University

      5. CD14+CD33+HLA-DR- monocytic-Myeloid derived suppressor cells (M-MDSCs) recruited and activated by CCR9/CCL25 is crucial for pathogenic progression of endometriosis - Yin-Yan He, Shanghai JiaoTong University

      6. PI3Kγ play an important role in CD14hi Cells Differentiation in Endometriosis - Chun-Yan Wei, FuDan University

      B3: Immunology of Implantation and Assisted Reproductive Technology   

      Chairs: Yuan-Qing Yao, Joanne Kwak-Kim

      1. The regulatory roles of decidual glycodelin-A on trophoblast and immune cell functions during early pregnancy - C.N. Philip, University of Hong Kong, China

      2. Precision medicine for NK cell-mediated immunopathology in women with reproductive failure - Joanne-Kwak Kim, Rosalind Franklin University
      3. Autoantibodies against ß2-glycoprotein I/HLA class II complexes in women with recurrent pregnancy - Kenzi Tanimura, Kobe University

      4. Role of IL-22 cytokine in cycling endometrium and in pregnancy - Svetlana Dambaeva, Rosalind Franklin University

      10:00-10:15 Coffee Break

      B1: Novel Aspects of Maternal-Fetal Immune Regulation II  

      Chairs: Ming-Qing Li, Evan Ntrivalas

      1. PD-1 regulating macrophage polarization at the maternal-fetal interface - Aihua Liao, Huazhong University
      2. Role of ionized magnesium testing in pre-eclampsia - Evan Ntrivalas, Nova Biomedical
      3. IL-1 receptor antagonist improves trophoblast invasion, endothelial development and ZIKV sequelae in offspring - Jun Lei, Johns Hopkins University SOM

      4. Peripheral blood effector Treg cells decreased in premature ovarian insufficiency cases - Osamu Yoshino

      5. CMKLR1 signaling pathway plays a role in trophoblast invasion via regulating uterine NK cells - Qing-Qing Zhang

      B2: Reproductive Endocrine-Metabolo-Immunology Networks II    

      Chairs: Xiao-Yong Zhu, Emmet Hirsch

      1. Insights of efferocytosis in diseases of OB/GY - Xiao-Yong Zhu, FuDan University
      2. Is Labor an Inflammatory Condition? - Emmet Hirsch, Northshore University Health System
      3. A study of CD1a+ and CD83+ dendritic cells in the endometrium of women with recurrent miscarriage - Su Liu, Shenzhen Zhongshan Urology Hospital, China

      4. FGL2 plays an important role in the pathogenesis of endometriosis through promoting proliferation and invasion of endometrial stromal cells - Xin-Xin Hou, FuDan University, China

      5. Serum chemerin level associated with spontaneous abortion in PCOS Women - Xue-Zhou Yang, Xiangyang Central Hospital

        B3: Immunology of Implantation and Assisted Reproductive Technology II 

        Chairs: Wei He, Xiao-Hong Wang

        1. Study for immune mechanism in the autoimmune ovarian disease - Wie He, Army Medical University

        2. The role of NK cells in ART and recurrent miscarriage - Li Hua Chen, Air Force Medical University, China

        3. LPS induces preferential enrichment of miRNAs in placental EVs to modulate inflammatory response in a paracrine manner - Xin-Hua Lin, NYU Winthrop Hospital, USA
        4. Morphology of endometrium of women with extracorporal fertilization in anamnesis - Larisa Vladimirovna Volkova
        5. Role of immunomodulation treatment (Lymphocytes Immunization Therapy - LIT) in the treatment of unexplained recurrent implantation failures (URIF) - Mohan Raut

        12:00-1:00     Lunch Break

        1:00 -  3:30 BREAKOUT SESSIONS:

        B4: Microbes and Mucosal Immunology in Reproductive Tract   

        Chairs: Yi-Zhun Zhu, Raina Fichorova

        1. The Maternal Microbes are Us - Raina Fichorova, Harvard University

        2. Immune-response and pharmacological effects of novel natural compounds - YiZhun Zhu, Macau University
        3. The changing landscape of the female genital tract microbiome - Sujata Srinivasan, Fred Hutchinson Cancer Research Center

        4. Endometrial NK and plasma cells in infertile women - Udo Markert, Universitats Klinikum Jena
        5. Innate immune system in the oviduct mucosa of hens - Yukinori Yoshimura, Hiroshima University

        6. Adrenomedullin suppresses macrophage activities in human oviduct: a patho-physiologic explanation of tubal ectopic pregnancy - Xia Wang, HongKong University, China

        B5: Tumor Immunology in Reproductive System and Others 

        Chairs: Xiao-Jun Chen, Benjamin Tsang

        1. Chemoresistant ovarian cancer: exosome-mediated immune cell tumor cell crosstalk in the tumor microenvironment - Benjamin Tsang, Ottawa University

        2. Chronic inflammatory microenvirement and estrogen regulation in endometrial cancer - Xiao-Jun Chen
        3. The role of autophagy for pathophysiology of preeclampsia: Correlation between trophoblasts-specific Atg7 knockout-mediated poor placentation and human preeclamptic placentas - Akitoshi Nakashima, University of Toyama

        4. The immune metabolic adaptations during early pregnancy: lessons learned from tumor immunology - Liang-Hui Diao, University Medical Center Hamburg-Eppendorf & Shenzhen Zhongshan Urology Hospital
        5. The testicular germ cell tumour line, TCam-2, drives M0 and M1 (THP-1-derived macrophages) the immunosuppressive M2 phenotype - Dana Pueschl, Hudson Institute 

        6. IL-27/GM-CSF signal is difficult to activate eosinophils in cervical cancer by STAT1 inactivation - Wen-Jie Zhou, Fudan University

        B6: HIV and Reproductive Tract Immunity

        Chairs: Charles Wira, Nadia Roan

        1. Impact of Sex Hormones, Hormonal Contraceptives and Antiretrovirals on Susceptibility to HIV Acquisition in the Human Female Reproductive Tract - Charles Wira, Dartmouth University

        2. The genital mucosa microenvironment and HIV: How a virus can co-opt host factors to promote its transmissionNadia Roan, University of San Francisco
        3. The virtue of simplicity: the vaginal microbiome, genital inflammation and HIV risk - Doug Kwon, Harvard University

        4. Understanding HIV risk in young women: A Mucosal Perspective - Jo-Ann Passmore, University of Cape Town
        5. The role of neutrophils in protection against HIV infection in the female genital tract - Marta Rodriguez Garcia, Dartmouth University

        3:30-3:45 Coffee Break

        3:45-5:30 Poster Viewing/Presentations by Authors

        3:45-5:00  AJRI Editorial Meeting  (3F Wyndham Hangzhou Room)

        6:30-8:30 Gala Dinner Cruise on Huangpu River

        Sunday, July 1 - Annual Meeting

        8:00-10:00 BREAKOUT SESSIONS:

        B7: The Male Reproductive Immunology I

        Chairs: Yong-Gang Duan, Andreas Meinhardt

        1. Testicular Autoimmunity – Are Sugars and Galectins the Key? - Monika Fijak, University of Giessen
        2. Chronic epidididymitis and male infertility -Yong-Gang Duan, Hong Kong University
        3. Innate defense in the male genital system - Daishu Han, Peking Union Medical College
        4. The Immune Response in Pregnancy begins before Fertilization - Ken Beaman, Rosalind Franklin University

        B8: Traditional Chinese Medicine in Reproductive Immunology I 

        Chairs: Hui-Lan Du, Fang Lian

        1. The intestinal flora characteristics of endometriosis and intervention of traditional Chinese medicine - Chao-Qin Yu, Changhai Hospital
        2. Study of the regulation of reproductive immunity by Chinese medicine - Hui-Lan Du, Hebei Medical University
        3. Difference in composition of vaginal microbiota between women exhibiting spleen deficiency syndrome and women with damp-heat syndrome - Song-Ping Luo, Guangzhou University of Chinese Traditional Medicine
        4. The Regulating Effect of Erzhi tiangui Particles in Maternal Fetal Tolerance in Embryo Implantation Based on the Role of NF-κB Signaling Pathway - Fang Lian, Shangdong University of Chinese Traditional Medicine

        5. Positive effects and molecular mechanisms of traditional Chinese medicine on embryo implantation - Ming-Min Zhang, Tongji Hospital, China

        6. Chinese herbal formula BSNXD prevents bone loss by modulating T cells and cytokine production in the OVX-mouse model for postmenopausal osteoporosis - Ling Wang

        B9: Immune-Related Pregnancy Complications I 

        Chairs: Zhi-Nan Yin, Surendra Sharma

        1. Novel Concepts of Tauopathy and Protein Toxicity in Preeclampsia: Mechanistic Similarities with Alzheimer’s Disease and CTE - Surendra Sharma, Women & Infants Hospital

        2. Microbiota and immune function - ZhiNan Yin, JiNan University
        3. Placenta-specific miR-519c-mediated induction of endotoxin tolerance in human placenta - Nazeeh Hanna, NYU Winthrop Hospital
        4. Secretory leukocyte protease inhibitor as a key regulator of cervical maturation - Takeshi Nagamatsu,University of Tokyo 

        10:00-10:15 Coffee Break

        10:15-12:00  BREAKOUT SESSIONS:

        B7: The Male Reproductive Immunology II

        Chairs: Chen Xu, Malini Laloraya

        1. Effects of MAPK Phosphatase-1 in testicular immunological microenvironment - Cheng Xu, Shanghai JiaoTong University
        2. Novel non-immune role of  the Autoimmune Regulator (AIRE) in collaboration with DOCK180 directs decidualization to enable successful pregnancy - Malini Laloroya, Rajiv Gandhi Centre for Biotechnology, India

        3. Association between Chlamydia trachomatis infection, semen quality and sperm acrosome reaction - Wen-Si Huang, ShenZhen ZhongShan Urology Hospital

        4. Relationship between Prostaglandins and Interleukins concentrations in seminal fluid and fertilization rate - Yazan Dabbour, Saarland University
        5. Delineating the testicular leukocyte population in the adult mouse testis and the macrophage population during postnatal development - Sivanjah Indumathy, Justus-Liebig University

        B8: Traditional Chinese Medicine in Reproductive Immunology II 

        Chairs: SongPing Luo, MingMin Zhang

          1. Study on reproductive disorders under light pollution and intervention measures of traditional Chinese medicine - Yong Tan, Nanjing University of Chinese Traditional Medicine
          2. The Effect and Mechanism of Traditional Chinese Medicine “Gengnianchun” in Anti-aging - Wen-Jun Wang, FuDan University

          3. Clinical evaluation of traditional Chinese medicine in management of recurrent abortion - Ji Li, Shanghai University of Chinese Traditional Medicine   
          4. Multi-centre research of traditional Chinese medicine in the treatment for poor ovarian response patients undergoing in vitro fertilization embryo transplantation - Wen Li, Nanjing University of Chinese Traditional Medicine
          5. The application of traditional Chinese medicine for tonifying kidney and activating blood in the treatment  of URSA - Xiao-Ling Feng, Heilongjiang University of Chinese Traditional Medicine
          6. Effectiveness of reduction natural killer lymphocyte cytotoxicity by repeated cupping manipulation depends on NK phenotype - Boris Donskoy, National Academy of Medical Sciences of Ukraine
          7. Bu-Shen-Ning-Xin decoction suppressed osteoclastogenesis by modulating RANKL/OPG imbalance in CD4+ T lymphocytes of ovariectomized mice - Jia Li Zhang, FuDan University

            B9: Immune-Related Pregnancy Complications II  

            Chairs: Xun Qu, Irina Burd

            1. Maternal Immunomodulation for Prevention of Adverse Perinatal Outcomes: The New Era of Immuno-Perinatology - Irina Burd, Johns Hopkins University

            2. Cervical Viral Infection During Pregnancy - Karen Racicot, Michigan State University
            3. Natural killer cells help nourish fetus during early pregnancy - BinQing Fu, University of Science & Technology, China
            4. Is Intra-uterine Growth Restriction Associated with a Pro-inflammatory Cytokine Bias? - Raj Raghupathy, Gulf University of Science and Technology 
            5. Abnormal placental lymphangiogenic factor expression is associated with choriodecidual lymphangiogenesis in severe preeclampsia - Ja Young Kwon, Yonsei University

            12:00-1:00 Lunch Break

            1:00-3:00  Closing Ceremony

            • Closing Keynote Address: Materno-Fetal Immune Regulation and Its Translation - Meirong Du
            • Closing Remarks - DaJin Li & Nazeeh Hanna

            2:00-3:00 ASRI Business Meeting

            2:30-4:00 ASRI Council Meeting II

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