Welcoming Remarks and Introduction

Gil Mor, MD PhD, Yale University

President’s Distinguished Lecture

Tippi MacKenzie, MD

University of California, San Francisco

ASRI Award Lecture - Irina Burd, MD, PhD, Johns Hopkins Medical Institute

Braverman Award Lecture - Jun Lei, PhD, Johns Hopkins University

Immunomodulatory therapies for prevention of ZIKV congenital infection

Chair: Ja-Young Kwon, MD, PhD, Yonsei University

S01.1 - David Aronoff, MD, Vanderbilt University

Macrophages in host defense against Group B streptococcal chorioamnionitis

S01.2 - Nabila Jabrane-Ferrat, PhD, CPTP-INSERM

Viral pathogenesis at the maternal-fetal interface

Relevance of placental type I interferon in the regulation of host-pathogen interactions

OR01 - Ryan Doster, PhD, Vanderbilt University Medical Center

The role of Streptococcus agalactiae cadD in metal efflux, survival in macrophages, and ascending vaginal infection during pregnancy

OR02 - Rebecca Casazza, PhD, University of North Carolina

Interferon lambda signals to maternal tissues to limit Zika virus transplacental transmission in mice

Chair: Charles H. Graham, PhD, Queen's University, Virginie Gaudreault, Universite de Montreal

S02.1 - Stephan Renaud, PhD, University of Western Ontario

Natural killer cells: friends, foes, and implications for preeclampsia

Antiphospholipid antibodies and dangerous extracellular vesicles from the syncytiotrophoblast

S02.3 - Sylvie Girard, PhD, Universite de Montreal

Maternal Immune Mediated Endothelial Activation in Preeclampsia

OR03 - Cyntia Duval, PhD, Universite de Montreal

Altered transcriptome profiles in placentas from complicated pregnancies in association with adverse neonatal outcomes

OR04 - Caroline Dunk, PhD, Lunenfeld Tanenbaum Research Institute

The STOX1 genotype associated with severe preeclampsia negatively affects extravillous trophoblast-leukocyte mediated uterovascular remodelling in early pregnancy

Chairs: Keith English, PhD, Michigan State University & Richard Leach, MD, Michigan State University

Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression

S03.3 - Nigel Paneth, MD, Michigan State University

Inflammation-related proteins in the first weeks of life and neurodevelopment in extremely low gestational age newborns (ELGANs)

Exposure of the Fetus to Bacteria in Pregnancy: Physiological Exposure of the Fetus to Antigens in the Maternal Environment?

Chairs: Abey Eapen, PhD, Univ. of Iowa & Soo Hyun Ahn, PhD, Michigan State Univ.

Intravenous immunoglobulin G infusion treatment for women with recurrent pregnancy losses and repeated implantation failures

Immunosuppressive treatment with tacrolimus improves reproductive outcome of women with repeated implantation failures who have elevated Th1/Th2 cell ratios

Natural Killer cell education and unexplained infertility

Personalization of assisted reproductive treatments in function of the endometrial immune profile

Grand Rapids Brewery Tours (optional group event)

 Meet in hotel lobby

PL03: Meeting Chair’s Session

Evolutionary Role of the Immune System in Reproduction

Chairs: Karen Racicot, PhD, Michigan State University, Troy Ott, PhD, Penn State University

PL03.1 - Gunter Wagner, PhD, Yale University

Evolutionary modification of the inflammatory reaction at the fetal-maternal interface

PL03.2 - Thomas Spencer, PhD, University of Missouri

The evolution of the placenta

Co-option of immune system molecules by the placenta

Chair: Kaori Koga, MD, University of Tokyo & Yosuke Ono, PhD, Tonami General Hospital

The involvement of Damage-associated molecular patterns (DAMPs) and macrophages in the etiology of endometriosis

Immune dysfunction in endometriosis

S05.3 - Kaori Koga, MD, University of Tokyo

Peritoneal Immune Cells in the Pathogenesis of Endometriosis

OR05 - Yosuke Ono, PhD, University of Toyama, Japan

The role of M2 macrophage in endometriosis

OR06 - Nhung Le, PhD, Southern Illinois University

Alteration of Microbial Communities and Immune Populations in Patients with Endometriosis

Chairs: Andrea Braundmeier-Fleming, PhD, Southern Illinois University

S06.1 - Andrea Braundmeier-Fleming, PhD, Southern Illinois University

The Impact of Maternal Inflammation on Preterm Birth

Ralstonia insidiosa: Introducing a bona fide microbial resident in the placenta

Does the human placenta delivered at term have a microbiota?

OR07 - Haley Dupont, PhD, McMaster University

Examining the effect of the vaginal microenvironment on growth and colonization of Lactobacillus species

OR08 - Ramakrishna Kommagani, PhD, Washington University St. Louis

The gut microbiota drives endometriosis by promoting inflammation

LUNCH BREAK

MENTOR/TRAINEE LUNCH    Click for Details

Chair:  Sylvie Girard, PhD, Universite de Montreal

Chairs: Vikki Abrahams, PhD, Yale University, Mancy Tong, PhD, Yale University

S07.1 - Mancy Tong, PhD, Yale University

Mechanisms of Fetal Membrane Induced Neutrophil Activation and Extracellular Trap Release

S07.2 - Nardhy Gomez-Lopez, PhD, Wayne State University

S07.3 - Ramkumar Menon, PhD, University of Texas Medical Branch

OR09 - Jennifer Gaddy, PhD, Vanderbilt University Medical Center

The role of zinc homeostasis in Group B Streptococcus biofilm formation in vitro and in an instrumented fetal membrane on a chip

OR10 - Kenichiro Motomura, PhD, Wayne State University

Diverse host-pathogen interactions in intra-amniotic infections associated with genital mycoplasmas

Chairs: Indira Mysorekar, PhD, Washington University & Elaine Parker, PhD, Washington University

Transgenerational Consequences of Developmental Toxicant Exposure of the Male

Seminal plasma is more than a swimming pool for sperm: the potential for semen components to contribute to pregnancy outcomes

Current concepts in male reproductive immunophysiology - immunoregulation, inflammation and infertility

OR11 - Yongning Lu, PhD, Fudan University

Uropathogenic E. Coli Infection compromises blood-testis barrier by disturbing mTORc1-mTORc2 balance

OR12 - Aihua Liao, PhD, Huazhong University of Science and Technology

Expression and localization of PD-1 and PD-L1 in mouse testes

Chair: Ana Zenclussen, PhD, Otto-von-Guericke University & Anne Schumacher, PhD, Otto-von-Guericke University

The human fetal intestine is enriched for pro-inflammatory PLZF+ CD4+ T cells associated with preterm birth

Mating induces expansion, phenotypic modulation and epigenetic alteration in Foxp3 within the thymus-derived regulatory T cells in mice

Feto-maternal communication during pregnancy

OR13 - Ruth Marian Guzman-Genuino, PhD, University of South Australia

Maternal B cells contribute to the regulation of inflammatory processes required for successful implantation

OR14 - Na Shin, PhD, Johns Hopkins Medical Institute

Serum amyloid A may provide a link between maternal inflammation and placental dysfunction

S-10: Immune Modulation of Reproductive Malignancies

Chairs: Animesh Barua, PhD, Rush University & Ronald Chandler, PhD, Michigan State University

In Search of Early Diagnosis and Immunotherapeutic Strategy for Chemoresistant Ovarian Cancer in the Era of Personalized Cancer Medicine

Mechanistic role of SWI/SNF chromatin remodeling in inflammation-associated gynecologic cancers

Neutrophils as hypoxia-regulated anti-tumor effectors in endometrial cancer

OR15 - Alpana Sharma, PhD, All India Institute of Medical Sciences

Clinical significance of autophagy related molecules in liquid biopsy of cervical cancer

OR16 - Animesh Barua, PhD, Rush University

Ovarian tumor-induced suppression of anti-tumor function of NK cells and strategies for its prevention