The American Society for 

Reproductive Immunology

wednesday, june 12

 12:00 PM - 6:00 PM Registration  Center Concourse
 1:00 PM - 3:00 PM Executive Council Meeting  Pearl Room
 5:00 PM -  5:10 PM Welcome Remarks

Gil Mor, MD PhD, Yale University

Karen Racicot, PhD, Michigan State University

Richard Leach, MD, Michigan State University

 Pantlind Ballroom
 5:10 PM - 6:00 PM

PL01: Keynote Lecture

Chairs: Gil Mor, MD PhD, Yale University, Karen Racicot, PhD, Michigan State University

Judith Van de Water, PhDUC Davis MIND Institute 

UC Davis Center for Children’s Environmental Health

Professor, Department of Internal Medicine, UC Davis School of Medicine

 Pantlind Ballroom
 
 
 6:00 PM - 7:30 PM

WELCOME RECEPTION  -  Cocktails & Hors D'oeuvres

 Center Concourse

thursday, june 13

 7:00 AM - 8:00 AM BREAKFAST  Center Concourse
 7:30 AM - 5:00 PM Registration  Center Concourse
 8:00 AM - 10:00 AM PL02: President's Session  Ambassador Ballroom
8:00-8:10 

Welcoming Remarks and Introduction

Gil Mor, MD PhD, Yale University

 
8:10-9:00 

President’s Distinguished Lecture


Tippi MacKenzie, MD

University of California, San Francisco

 
9:00-9:45 

ASRI Award Lecture - Irina Burd, MD, PhD, Johns Hopkins Medical Institute

 
9:45-10:00 

Braverman Award LectureJun Lei, PhDJohns Hopkins University

 
     
10:00 AM - 10:30 AM COFFEE BREAK  Center Concourse
     
10:30 AM - 12:30 PM S-01: Host-Pathogen Interactions in the Reproductive Tract 

Chairs: Malini Laloraya, PhD, Rajiv Gandhi Center for Biotechnology,  Ja-Young Kwon, MD, PhD, Yonsei University

 Ambassador East
10:30-11:00 

S01.1 David Aronoff, MD, Vanderbilt University

Macrophages in host defense against Group B streptococcal chorioamnionitis

 
11:00-11:30 

S01.2 - Nabila Jabrane-Ferrat, PhD, CPTP-INSERM

Viral pathogenesis at the maternal-fetal interface

 
11:30-12:00  S01.3 -  Ja-Young Kwon, MD, PhD, Yonsei University

Relevance of placental type I interferon in the regulation of host-pathogen interactions

 
12:00-12:15 

OR01 - Ryan Doster

The role of Streptococcus agalactiae cadD in metal efflux, survival in macrophages, and ascending vaginal infection during pregnancy

 
12:15-12:30 

OR02 - Rebecca Casazza

Interferon lambda signals to maternal tissues to limit Zika virus transplacental transmission in mice

 
 
 
10:30 AM - 12:30 PM S-02: Contribution of Maternal Immune System to the Etiology of Pre-Eclamsia

Chair: Charles H. Graham, PhD, Queen's University, Tiziana Cotechini, PhD, Queen's University

 Ambassador West
10:30-11:00 

S02.1 - Stephan Renaud, PhD, University of Western Ontario

Natural killer cells: friends, foes, and implications for preeclampsia

11:00-11:30  S02.2 - Lawrence Chamley, PhD, University of Auckland 

Antiphospholipid antibodies and dangerous extracellular vesicles from the syncytiotrophoblast

 
11:30-12:00 

S02.3 - Sylvie Girard, PhD, Universite de Montreal

Maternal Immune Mediated Endothelial Activation in Preeclampsia

 
12:00-12:15 

OR03 - Cyntia Duval

Altered transcriptome profiles in placentas from complicated pregnancies in association with adverse neonatal outcomes

 
12:15-12:30 

OR04 - Caroline Dunk

The STOX1 genotype associated with severe preeclampsia negatively affects extravillous trophoblast-leukocyte mediated uterovascular remodelling in early pregnancy

 
   
12:30 PM - 2:00 PM LUNCH BREAK  
     
2:00 PM - 4:30 PM S-03: Perinatal Influences on Neurodevelopment  

Chairs: Keith English, PhD, Michigan State University & Richard Leach, MD, Michigan State University

 Ambassador East
 2:00-2:30 

S03.1 - Suresh Boppana, MD, University of Alabama, Birmingham

Congenital CMV Infection and Neurologic Morbidity

 
2:30-3:00  S03.2 - Daniel Campbell, PhD, Michigan State University

Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression

 
3:00-3:30 

S03.3 - Nigel Paneth, MD, Michigan State University

Inflammation-related proteins in the first weeks of life and neurodevelopment in extremely low gestational age newborns (ELGANs)

 
3:30-4:00  S03.4 - Charles Wood, PhD, University of Florida

Exposure of the Fetus to Bacteria in Pregnancy: Physiological Exposure of the Fetus to Antigens in the Maternal Environment?

 
4:00-4:30  Moderated Panel Discussion  
     
2:00 PM - 4:30 PM S-04: Pros and Cons of Immune-Modulatory Agent Use in Reproductive Medicine

Chairs: Abey Eapen, PhD, Univ. of Iowa & Soo Hyun Ahn, PhD, Michigan State Univ.

 Ambassador West
2:00-2:30  S04.1 - Joanne Kwak-Kim, MD, Rosalind Franklin University

Intravenous immunoglobulin G infusion treatment for women with recurrent pregnancy losses and repeated implantation failures

 
2:30-3:00  S04.2 - Koji Nakagawa, MD,  Sugiyama Clinic Shinjuku

Immunosuppressive treatment with tacrolimus improves reproductive outcome of women with repeated implantation failures who have elevated Th1/Th2 cell ratios


3:00-3:30  S04.3 - Svetlana Dambaeva, MD, PhD, Rosalind Franklin University

Natural Killer cell education and unexplained infertility

 
3:30-4:00  S04.4 - Nathalie Ledee, MD, INSERM

Personalization of assisted reproductive treatments in function of the endometrial immune profile

 
4:00-4:30  Moderated Panel Discussion   
     
5:00 PM - 7:00 PM

Grand Rapids Brewery Tours (optional group event)

 Meet in hotel lobby

 

friday, june 14

 7:00 AM - 8:00 AM BREAKFAST  Center Concourse
 7:30 AM - 5:00 PM Registration  Center Concourse
 8:00 AM - 9:45 AM

PL03: Meeting Chair’s Session

Evolutionary Role of the Immune System in Reproduction

Chairs: Karen Racicot, PhD, Michigan State University, Troy Ott, PhD, Penn State University

 Ambassador Ballroom
8:00-8:30 

PL03.1 - Gunter Wagner, PhD, Yale University

Evolutionary modification of the inflammatory reaction at the fetal-maternal interface

 
8:30-9:00 

PL03.2 - Thomas Spencer, PhD, University of Missouri

TBA 

 
9:00-9:30  PL03.3 - Douglas Antczak, VMD, PhD, Cornell University

Co-option of immune system molecules by the placenta

 
9:30-9:45  Moderated Panel Discussion  
     
 9:45 AM -10:00 AM  COFFEE BREAK  Center Concourse
     
10:00 AM - 12:00 PM S-05: Immune System Role in Pathogenesis of Endometriosis

Chair: Kaori Koga, PhD, University of Tokyo & Yosuke Ono, PhD, Tonami General Hospital

 Ambassador East
 10:00-10:30  S05.1 - Osama Yoshino, PhD, Toyama University

The involvement of Damage-associated molecular patterns (DAMPs) and macrophages in the etiology of endometriosis

 
10:30-11:00  S05.2 - Chandrakant Tayade, PhDQueen's University

Immune dysfunction in endometriosis

 
11:00-11:30  S05.3 - Erin Greaves, PhDThe Queen's Medical Research Institute

Endometriosis-associated macrophages: a complex population exhibiting different functions, phenotypes and ontogenies

 
11:30-11:45 

OR05 - Yosuke Ono

The role of M2 macrophage in endometriosis

 
11:45-12:00 

OR06 - Nhung Le

Alteration of Microbial Communities and Immune Populations in Patients with Endometriosis

 
     
10:00 AM - 12:00 PM S-06: The Impact of the Maternal Microbiome on Pregnancy and Fetal Outcomes

Chairs: Andrea Braundmeier-Fleming, PhD, Southern Illinois University

 Ambassador West
10:00-10:30 

S06.1 - Andrea Braundmeier-Fleming, PhD, Southern Illinois University

The Impact of Maternal Inflammation on Preterm Birth


10:30-11:00  S06.2 - Indira Mysorekar, PhD, Washington University

Ralstonia insidiosa: Introducing a bona fide microbial resident in the placenta

 
11:00-11:30  S06.3 - Kevin Theis, PhD, Wayne State University

Does the human placenta delivered at term have a microbiota?

 
11:30-11:45 

OR07 - Haley Dupont

Examining the effect of the vaginal microenvironment on growth and colonization of Lactobacillus species

 
 11:45-12:00 

OR08 - Ramakrishna Kommagani

The gut microbiota drives endometriosis by promoting inflammation

 
     
 12:00 PM - 1:00 PM

LUNCH BREAK


 
 12:00 PM - 1:00 PM

MENTOR/TRAINEE LUNCH 

Chair:  Sylvie Girard, PhD, Universite de Montreal

 Gerald Ford Ballroom
     
 1:00 PM - 3:00 PM S-07: Immune Function at the Fetal Membranes

Chairs: Vikki Abrahams, PhD, Yale University, Mancy Tong, PhD, Yale University

 Ambassador East
 1:00-1:30 

S07.1 - Mancy Tong, PhD, Yale University

Mechanisms of Fetal Membrane Induced Neutrophil Activation and Extracellular Trap Release

 
 1:30-2:00 

S07.2 - Nardhy Gomez-Lopez, PhD, Wayne State University

Intra-amniotic inflammasome activation in preterm labor
 
2:00-2:30 

S07.3 - Ramkumar Menon, PhD, University of Texas Medical Branch

Linking Fetal Membrane Infection with Senescence and Inflammation

 
 2:30-2:45 

OR09 - Jennifer Gaddy

The role of zinc homeostasis in Group B Streptococcus biofilm formation in vitro and in an instrumented fetal membrane on a chip

 
2:45-3:00 

OR10 - Kenichira Motomura

Diverse host-pathogen interactions in intra-amniotic infections associated with genital mycoplasmas

 
     
 1:00 PM - 3:00 PM S-08: Reproductive Immunology in the Male

Chairs: Indira Mysorekar, PhD, Washington University & Elaine Parker, PhD, Washington University

 Ambassador West
 1:00-1:30  S08.1 - Kaylan Bruner-Tran, PhD, Vanderbilt University

Transgenerational Consequences of Developmental Toxicant Exposure of the Male

 
1:30-2:00  S08.2 - John Bromfield, PhD, University of Florida

Seminal plasma is more than a swimming pool for sperm: the potential for semen components to contribute to pregnancy outcomes

 
2:00-2:30  S08.3 - Mark Peter Hedger, PhD, Hudson Institute

Current concepts in male reproductive immunophysiology - immunoregulation, inflammation and infertility

 
 2:30-2:45 

OR11 - Yongning Lu

Uropathogenic E. Coli Infection compromises blood-testis barrier by disturbing mTORc1-mTORc2 balance

2:45-3:00 

OR12 - Aihua Liao

Expression and localization of PD-1 and PD-L1 in mouse testes

 
     
 3:00 PM - 3:30 PM COFFEE BREAK  
     
 3:30 PM - 5:30 PM S-09: Role of Maternal and Fetal Immune Systems in Pregnancy Outcomes

Chair: Ana Zenclussen, PhD, Otto-von-Guericke University & Anne Schumacher, PhDOtto-von-Guericke University

 Ambassador East
3:30-4:00  S09.1 - Joanna Halkias, MD, UC San Francisco

The human fetal intestine is enriched for pro-inflammatory PLZF+ CD4+ T cells associated with preterm birth

 
 4:00-4:30  S09.2 - Lachlan Moldenhauer, PhDUniversity of Adelaide

Mating induces expansion, phenotypic modulation and epigenetic alteration in Foxp3 within the thymus-derived regulatory T cells in mice

 
4:30-5:00  S09.3 Ana Zenclussen, PhD, Otto-von-Guericke University

Feto-maternal communication during pregnancy

 
 5:00-5:15 

OR13 - Ruth Marian Guzman-Genuino

Maternal B cells contribute to the regulation of inflammatory processes required for successful implantation

 
 5:15-5:30 

OR14 - Na Shin

Serum amyloid A may provide a link between maternal inflammation and placental dysfunction

 
     
 3:30 PM - 5:30 PM

S-10: Immune Modulation of Reproductive Malignancies

Chairs: Animesh Barua, PhD, Rush University & Ronald Chandler, PhD, Michigan State University

 Ambassador West
 3:30-4:00  S10.1 - Benjamin Tsang, PhD, University of Ottawa

In Search of Early Diagnosis and Immunotherapeutic Strategy for Chemoresistant Ovarian Cancer in the Era of Personalized Cancer Medicine

 
4:00-4:30  S10.2 - Ronald Chandler, PhD, Michigan State University

Mechanistic role of SWI/SNF chromatin remodeling in inflammation-associated gynecologic cancers

 
4:30-5:00  S10.3 - Adrian Erlebacher, MD, PhD, Univ. California San Francisco

Neutrophils as hypoxia-regulated anti-tumor effectors in endometrial cancer

 
5:00-5:15 

OR15 - Alpana Sharma

Clinical significance of autophagy related molecules in liquid biopsy of cervical cancer

 
5:15-5:30 

OR16 - Animesh Barua

Ovarian tumor-induced suppression of anti-tumor function of NK cells and strategies for its prevention

 
 
 
6:00 PM - 7:30 PM AJRI Editorial Board Meeting   TBA


saturday, june 15

 7:00 AM - 8:00 AM BREAKFAST  Center Concourse
 7:30 AM - 5:00 PM Registration  Center Concourse
     
 8:00 AM - 9:30 AM PL04: Gusdon Award Session  Ambassador Ballroom
 8:00-8:15 

G01 - Sean Nguyen

Trafficking of placental extracellular vesicles in murine pregnancy

 
 8:15-8:30  G02 - Lea Lentz

Human chorionic gonadotropin favors fetal tolerance by regulating the Treg/TH17 balance and promoting anti-inflammatory T cell responses in mice

 
8:30-8:45 

G03 - Qian Chen

Zika virus subverts the placental lipidome to induce inflammation

 
8:45-9:00 

G04 - Ramtin Ghasemi

The effect of estradiol on B cell responses against herpes simplex virus type 2

 
9:00-9:15 

G05 - Alison Eastman

Decidual Stromal Cells and Cytotrophoblasts Synergize to Dampen and Modulate Macrophage Activation in Response to Group B Streptococcus Infection

 
9:15-9:30 

G06 - Valeria Garcia-Flores

Adoptive transfer of in vitro M2-polarized macrophages prevents preterm birth and neonatal mortality

 
     
9:30 AM - 11:00 AM PS01: Poster Session  Ambassador Foyer
     
11:00 AM - 12:30 PM  LUNCH BREAK  on your own
     
12:30 PM - 2:30 PM S-11:  Sexually Transmitted Infections

Chairs: Charles Wira, PhD, Dartmouth University & Marta Rodriguez Garcia, PhD, Dartmouth University

 Ambassador East
 12:30-1:00 S11.1 - Marta Rodriguez Garcia, PhD, Dartmouth University

Changes in Mucosal Immunity that Influence Susceptibility to HIV-infection before and after Menopause

 
1:00-1:30

S11.2 - Caroline Attardo Genco, PhD, Tufts University

Sex as a Variable: Distinct Gonococcal Gene Signatures Expressed During Natural Human Mucosal Infection in Men and Women
 
1:30-2:00 

S11.3 - Wilbert Derbigny, PhD, Indiana University

TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection

 
2:00-2:15 

OR17 - Mimi Ghosh

Stress Response and Immune Dysregulation Following Acute Sexual Trauma Exposure in Women at High Risk of HIV

 
2:15-2:30 

OR18 - Clare Gyorke

Interleukin-1 alpha drives oviduct pathology by enhancing immune cell recruitment, cell death, and bacterial ascension during Chlamydia muridarum infection

 
     
12:30 PM - 2:30 PM

S-12: Tissue-Associated Innate Lymphoid Cell Function During Pregnancy

Chairs: Dorothy Sojka, PhD, Washington University St. Louis & Margaret Petroff, PhD, Michigan State University

 Ambassador West
 12:30-1:00  S12.1 - Binqing Fu, PhD, University of Science and Technology of China

CD49a+ tissue-resident-natural killer cells promote fetal development in early pregnancy

 
1:00-1:30  S12.2 - Aleksandar Stanic-Kostic, University of Wisconsin

Plastic Fantastic: Transcriptional Malleability and Functional Stability of Decidual Innate Lymphoid Cells

 
1:30-2:00  S12.3 - Dorothy Sojka, PhD, Washington University St. Louis

Uterine Tissue-Resident NK Cells

 
2:00-2:15 

OR19 - Huili Yang

Decidual stromal cells promote the differentiation of CD56brightCD16-NK cells by secreting IL-24 in early pregnancy

 
2:15-2:30 

OR20 - Boris Dons'koi

IvIg treatment neutralizes the negative effect of elevated NK cytotoxicity in IVF

 
     
 2:30 PM - 3:00 PM COFFEE BREAK  Ambassador Foyer
     
 3:00 PM - 5:00 PM

S-13: Placental Immune Function as a Predictor of Maternal and Fetal Health Outcomes 

Chair: Jennifer Gilner, MD, PhD, Duke University & Joanna Halkias, MD, UC San Francisco

 Ambassador East
 3:00-3:30  S13.1 - Thaddeus Golos, PhD, University of Wisconsin-Madison

Non-human primate models of pathogen responses at the maternal-fetal interface

 
3:30-4:00  S13.2 - Alexandre Bonnin, PhD, University of Southern California

Stress and inflammation effects on the placenta-fetal brain axis: an early neurotransmitter perspective

 
4:00-4:30  S13.3 - Jennifer Gilner, MD, PhD, Duke University

Deciphering the Reproductive Rosetta Stone: Placental immunology predictions of maternal and fetal health

 
4:30-4:45 

OR21 - Marie-Eve Brien

Non-infectious inflammation during pregnancy is associated with fetal growth restriction and altered neurodevelopment

 
4:45-5:00  OR20 - Meredith Kelleher

Altered fetal hemodynamic status and neuroinflammation in a nonhuman primate model of intrauterine Ureaplasma parvum infection

 
     
3:00 PM - 5:00 PM S-14: Role of Maternal Vaccinations in Protecting Against Neonatal Diseases

Chair:  Beth Holder, PhD, Imperial College London & Linda Eckert, PhD, University of Washington

 Ambassador West
 3:00-3:30  S14.1 -  Beth Holder, PhD, Imperial College London

The Impact of Maternal Pertussis Vaccination on the Maternal and Infant Immune System

 
3:30-4:00  S14.2 - Margaret Ackerman, PhD, Dartmouth College 

Protective antibodies twice removed - prospects for inherited passive immunity

 
4:00-4:30  S14.3 - Linda Eckert, PhD, University of Washington

Moving Maternal Immunization Forward with Standardized Definitions and Data Collection Tools

 
4:30-4:45 

OR23 - Mohan Raut

Immunomodulation with lymphocyte immunization therapy (LIT) and other immunomodulators in unexplained recurrent IVF failures - is it worth?

 
4:45-5:00 

OR24 - Puja Bagri

Estradiol enhances anti-viral CD4+ tissue-resident memory T cell responses following mucosal HSV-2 immunization

 
 
 
5:00 PM - 6:00 PM Cocktail Reception  East Concourse
6:00 PM - 7:30 PM  Awards Dinner & Closing Remarks  Pantlind Ballroom
7:30 PM - 9:30 PM Entertainment / Dancing  
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