“Bridging immunity with infection, inflammation and implantation for better reproductive health”

Sunday Sept 17, 2017

4:45-5:00 PM               Welcome and Announcements – LaSalle I

Meeting Chairs’ Greeting - Drs. Animesh Barua, Michael Bradaric and Joanne Kwak-Kim

President of ASRI address - Nazeeh Hanna, MD

5:00-6:00 PM             Keynote Address 

Chair: Animesh Barua, PhD

 Jan Bresch, Executive Vice President and Chief Operating Officer, Prevent Cancer Foundation 

S13: “Think about the link®: A case study of a U.S. based campaign tackling public awareness of certain virally-induced cancers” 

6:30-7:30 PM              Welcome Reception – LaSalle II

7:30-9:00 PM               AJRI editorial meeting – Huron Room

Monday, Sept 18, 2017           

7:30-8:30 AM               Breakfast – State Foyer

7:00-5:00 PM               Registration – State Foyer

Session 1: New advances in innate immune mechanisms at the maternal fetal interface and reproductive tumors

Chairs: Edward Barker, PhD and Margaret Petroff, PhD

8:30-8:50 AM               Edward Barker, PhD, Rush University

S14: The implications for activating receptor expression on cervical natural killer cells and their ability to respond to HIV-infected

8:50-9:10 AM               Andrew Wilber, PhD, Southern Illinois University School of Medicine

S15: Conversion of natural killer cell phenotype and function by tumor immune modulators

9:10-9:30 AM              Oral Presentation selected from abstracts (10 min each)

Dr. Yasuyuki Negishi, Nippon Medical School, Japan

O1 : Accumulation of dendritic cells and invariant natural killer T cells in decidua of late preterm birth without acute chorioamnionitis

Dr. MW Schroeder, Southern Illinois School of Medicine

O2: Hypoxia mediated endoplasmic reticulum stress: a mechanism for altered angiogenic gene expression in preeclampsia.

Session 2:  Presidential Session – LaSalle I

Chairs: Nazeeh Hanna, MD and Udo Markert, MD

9:30-10:00 AM             David M Aronoff, MD, FIDSA, Vanderbilt University Medical Center

S16: Immunological consequences of diabesity at the maternal-fetal interface

10:00-10:30 AM           Teresa K. Woodruff, PhD, Northwestern University

S17: What to watch: Three breakthroughs that may change our lives in the next 10 years

10:30-10:45 AM           Coffee Break – State Foyer

 

Session 3: Inflammation, immunity and pregnancy outcome

Chairs: Don Torry, PhD and Youssef Hussein, MD

10:45-11:10 PM            Serdar Bulun, MD, Northwestern University.

S18: Epigenetics, steroids, immune function and endometriosis

11:10-11:35 PM            Tomoyuki Fujii, MD, PhD, University of Tokyo, Japan

S19: Omega-3 polyunsaturated fatty acids and preterm birth

11:35-12:00 PM            Sarah Robertson, PhD, University of Adelaide 

S20: Targeting Toll-like receptor-4 (TLR4) to tackle preterm birth

12:00-1:00 PM             Lunch – State Foyer

12:00-1:00 PM             ASRI Executive Council Meeting – Huron Room

 

Session 4: John P Gusdon Award Competition – LaSalle I

Chairs: Chandrakant Tayade, DVM, PhD, Don Torry, PhD and Nayoung Kim, MD

1:00-2:15 PM               Top 6 ranked abstracts will present 12-minute oral presentations

Basic Science Candidates

1. O3: Dr. HM Ismaeel, Southern Illinois University School of Medicine – Potential role of JMJD6 in regulating soluble fms-like tyrosine kinase-1 splicing in human trophoblast
2. O4: Dr. P. Valenzuela, Universidad Austral de Chile, Chile – Docosahexanoic acid affects expression of proinflammatory factors on bovine endometrial cells
3. O5: Jun Lei, PhD, Johns Hopkins University School of Medicine – Maternal vascular malperfusion of placenta in response to intrauterine inflammation and its connection to fetal brain injury

Clinical Science Candidates

1. O6: Mahmood Bilal, PhD, Chicago Medical School at Rosalind Franklin University of Medicine and Science – Human peripheral blood mononuclear cells (PBMC) regulate their transcriptome through iodine and release thyroglobulin-derived thyroid hormones
2.  O7 (P67 in printed program): Annie Skariah – Evaluation of B cell subsets in women with recurrent pregnancy loss
3. O8: Ryu Takeyama, MD, Hyogo College of Medicine, Japan – The co-expression of activating and inhibitory receptors and cytokines production for uterine NK cells

 

2:15-3:30 PM               Poster Session I & Coffee Break – State Room (Odd Poster #s)

Chairs: Michael Bradaric, PhD, Li Wu, MD, PhD and Karen Racicot, PhD  

 

Session 5: AJRI Award Lecture – LaSalle I

3:30-4:00 PM               Chair: Gil Mor, MD, PhD

Udo Markert, MD, Universitätsklinikum Jena, Germany

S21: Ex vivo human placenta perfusion: from drug testing to microchimerism

Session 6: Immunological contribution by male in reproduction – LaSalle I

Chairs: Dale Hales, PhD and Silvia Daher, PhD

4:00-4:20 PM               David Miller, PhD, University of Illinois at Urbana-Champaign

S22: Sperm retention and release from the porcine oviduct reservoir prior to fertilization

4:20-4:40 PM               Akiko Hasegawa, PhD, Hyogo College of Medicine, Japan

S23: Possible Molecular Mechanism for Infertility in Women caused by Sperm Immobilizing Antibody (SI-Ab)

4:40-5:00 PM               Oral Presentation selected from abstracts (10 min each)

Dr. G S Gualdoni, Universidad de Buenos Aires, Argentina

O9: Relevance of angiogenesis in autoimmune testis inflammation

Dr. Hidenobu Miyaso, Tokyo Medical University, Japan

O10: The effect of neonatal exposure to lower dose decabromodiphenyl ether on transcript level of DNA methyltransferase 1 in mouse testes

 

5:30 PM                       Depart from Double Tree Hilton Hotel

6:00 PM                       Boarding for Dinner Cruise

6:15 PM                        Sail starts- Dinner Cruise at Navy Pier

Tuesday September 19, 2017

7:30-8:30 AM               Breakfast  – State Foyer

7:00-5:00 PM               Registration – State Foyer

7:00-8:00 AM               ISIR Council Meeting – Huron Room

Session 7: Gynecological tumors and current status on their treatment – LaSalle I

Chairs: Kenneth Beaman, PhD and Animesh Barua, PhD

8:30-9:00 AM               Kunle Odunsi, MD, PhD, Roswell Park Cancer Institute, University of Buffalo

S24: Tumor immunology and reproduction: Reprogramming T cells and hematopoietic stem cells for adoptive immunotherapy of relapsed ovarian cancer.

9:00-9:20 AM              Sameer Sharma, MD, Cook county Hospital, Chicago

S25: Metformin treatment may enhance anti-tumor immunity against ovarian cancer

9:20-9:45 AM              Oral Presentation selected from abstracts (12 min each)

Dr. Roslyn Tedja, Yale University School of Medicine

O11: Transimmunization reverses immune tolerance and improves survival in an ovarian cancer mouse model

Dr. M. Sheinin, Rush University

O12: Changes in NK-TR expression during the development and progression of ovarian cancer

Session 8: Stress and immunity in reproduction and reproductive diseases -LaSalle I

Chairs: Janice M Bahr, PhD and Shigeru Saito, MD, PhD

9:45-10:05 AM             Janice M Bahr, PhD, University of Illinois at Urbana Champaign

S26: High levels of FSH-associated chronic stress during aging may lead to ovarian cancer development

10:05-10:25 AM           Peter Hansen, PhD, University of Florida

S27: Colony stimulating factor 2 – not just a cytokine but an embryokine as well 

10:25-10:50 AM           Dale B. Hales, PhD, Southern Illinois University

S28: Nutritional intervention with anti-oxidant/anti-inflammatory diets for prevention of ovarian cancer in the laying hen

10:50- 11:05 AM          Coffee Break – State Foyer

 

Session 9: Abnormal immune function in ovary and its consequences in reproduction – LaSalle I

Chairs: George Ndukwe, MD and Dinorah Salazar, MD

11:05-11:25 AM           Frank González, MD, University of Illinois at Chicago

S29: Role of immune cell aberration on metabolic and ovarian dysfunction in polycystic ovary syndrome

11:25-11:45 PM            Benjamin Tsang, PhD, University of Ottawa, Canada

S30: Androgen and PCOS: dysregulation at the reproductive-metabolic-immunologic interphase

11:50-12:15 PM           Oral Presentation selected from abstracts (12 min each)

Tao Zhang, PhD, Shenzhen-Zhongshan Urology Hospital, China,  

O13: Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome

Li Wu, MD, PhD, Anhui Medical University, China

O14: The expression of vitamin D in follicular fluid in women receiving in vitro fertilization therapy

12:15-1:30 PM             Lunch – State Foyer

ASRI General Meeting (all members are invited) – LaSalle I

Session 10: J. Christian Herr Lecture – LaSalle I

Chairs: Alice Gilman-Sachs, PhD and Kuniaki Ota, MD

1:30-2:00 PM               Nazeeh Hanna, MD, Winthrop University Hospital and State University of New York at Stony Brook

S31: Placental endotoxin tolerance mediated by exosomal miRNAs

2:00-2:30 PM               Atsushi Fukui, MD, PhD, Hyogo College of Medicine, Japan

S32: NK cells and reproduction-our progress in NK cell study

2:30-2:45 PM               Coffee Break – State Foyer

 

Session 11: Organizers Special Session: Practice in Reproductive medicine: Legal aspects – LaSalle I   

Chairs: Animesh Barua, PhD and Michael Bradaric, PhD 

2:45-3:05 PM               James O’Donnell, PharmD,  Rush University

S33: Forensic analysis of adverse drug events and litigation claims in OB.GYN

Session 12: Co-stimulatory signals & pathways at maternal fetal interface – LaSalle I                                                 

Chairs: Kunle Odunsi, MD, PhD and Shihua Bao, MD

3:05-3:25 PM               Aihua Liao, MD, PhD, Tongji University, China

S34: Regulation of PD-1/PD-L1 signaling pathway on Treg/Th17 balance in pre-eclampsia

3:25-3:45 PM               Thomas Spenser, PhD, University of Missouri

S35: Interferon Tau and conception  

3:45-4:15 PM               Vikki M Abrahams, PhD, Yale University School of Medicine

S36: Mechanisms of inflammation and defective placentation in obstetric antiphospholipid syndrome

4:15- 6:00 PM              Poster session II – State Room  (Even Poster #s)

Chairs: Irina Burd, MD, PhD and Jun Lei, PhD  

 

6:30-7:30 PM               Cocktail hour –   State Foyer

7:30-10:00 PM             Gala and Awards Banquet – LaSalle II

Wednesday, September 20, 2017

7:30- 8:30AM             Breakfast – State Foyer

Session 13: Immune dysfunction in conception and abnormal Pregnancy – LaSalle I

Chairs: Fumihisa Chishima, MD and Ted Golos, PhD 

8:30-8:50 AM               Chandrakant Tayade, DVM, PhD, Queen’s University, Canada

S37: Immune dysfunction in endometriosis

8:50-9:10 AM              Aleksandar Stanic-Kostic, MD, PhD, University of Wisconsin-Madison

S38: To build and protect: leveraging machine learning to decipher the composition and function of the decidual immunome 

9:10-9:30 AM              Romana Nowak, PhD, University of Illinois at Urbana-Champaign

S39: Reproduction, uterine fibroid and immunity

9:30-10:15 AM             Oral Presentation selected from abstracts

Dinorah Salazar, MD, Chicago Medical School at Rosalind Franklin University of Medicine and Science

O15: Association between endometrial and peripheral blood immune profiles and reproductive outcome in patients with recurrent pregnancy loss (RPL) and repeated implantation failure (RIF)

Kuniaki Ota, MD, Nasu Red Cross Hospital, Japan

O16: A lack of vitamin D affects serum homocysteine level in women with recurrent pregnancy losses and MTHFR C677T polymorphism

Aparna Yellapa, PhD, Rush University

O17: Immunosuppression during the growth and development of uterine fibroids

Wen-jie Zhou, Fudan University

O18: The activation of FDP/IL-27 signaling in decidulization guarantees smooth gestation by triggering decidual M2 macrophage polarization

10:15-10:30 AM           Coffee Break – State Foyer

Session 14: MicroRNA and reproduction – LaSalle I

Chairs, Elizabeth Bonney, MD and Paulomi Aldo, PhD

10:30-10:50 AM           Joy Pate, PhD, The Pennsylvania State University

S40: MicroRNA as regulators of luteal function

10:50-11:10 AM           Margaret Petroff, PhD, Michigan State University

S41: Autoimmune-mediated infertility: Lessons from murine models

11:10-11:40 AM           Don Torry, PhD, University of Southern Illinois

S42: Roles and regulation of placenta growth factor in pregnancy

11:40-12:00 PM           Oral Presentation selected from abstracts (10 min each)

Dr. Akitoshi Nakashima, University of Toyama, Japan

O19: Autophagy inhibition leads to transthyretin overload and aggregation in human trophoblasts and hepatocytes: Novel implications for preeclampsia

Sung-Ki Lee, MD, PhD, Konyang University, Korea

O20: Unsaturated   acids protect trophoblast cells from saturated fatty acid-induced autophagy defects.

12:00-1:00 PM             Lunch – State Foyer

 

Session 15: HIV and genital infection, Zika virus infection: how much do we know? – LaSalle I

Chairs: Charles Wira, PhD and Joanne Kwak-Kim, MD

1:00-1:20 PM               Lena Al-Harthi, PhD, Rush University

S43: Insights into mechanisms driving Zika neuropathogenesis in utero

1:20-1:40 PM               Raina Fichorova, MD, PhD, Brigham and Women’s Hospital

S44:  Reproductive hormones and HIV:  Immunologic insights from the largest hormonal contraception and HIV study

1:40-2:00 PM               Peta Grigsby, PhD, Oregon Health & Science University

S45: Modeling Zika virus infection in pregnant rhesus macaques: Novel evidence of abnormal placental function and pathology

2:00-2:20 PM               Irina Burd, MD, PhD, John’s Hopkins University of Medicine

S46: Zika infection: Ceasefire at the expense of normal fetal development

2:20-3:00 PM               Oral Presentation selected from abstracts (10 min each)

Dr. Jason Daniels, The George Washington University

O21: Impact of recent sexual violence on genital tract matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) expression in women

Dr. N Strbo, University of Miami Miller School of Medicine

O22: Secreted gp96-Ig vaccination induces ZIKV specific CD8 T cell responses in decidua of B6 pregnant mice

 Dr. Alicynne Glazier, Michigan State University

O23: Cytomegalovirus IgG in maternal serum during pregnancy is associated with increased risk for behaviors associated with autism spectrum disorder in children

 Kenichiro Motomura, MD, National Research Institute for Child Health and Development, Japan

O24: Differentiated cytotrophoblasts induce anti-viral responses through receptors for double-stranded RNA

3:00 PM                       Meeting Adjourn