11:00 - 12:30

Clinical Course  Examinations

 3:00 PM - 4:30 PM

ASRI Executive Council Meeting (ASRI Council & Committee Chairs only)

 7:30 - 4:00 

Registration Desk open

Legends Foyer

 7:00 - 7:50 

Continental Breakfast for Clinical Course attendees

 Legends Foyer

  8:00 - 10:00

Clinical Course I: Laboratory Sciences and Reproductive Failures/ Rheumatology

Chair: Udo Markert

 8:00

Mahmood Bilal, Rosalind Franklin University - The role of extrathyroidal compound on immune and endometrial tissue

 8:30

Udo Markert, University of Jena - Immunological Aspects of Endometrium

 9:00

Theonia Boyd, Texas Children's Hospital - Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology I

Theonia Boyd, Texas Children's Hospital -- Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology II

 10:00 - 10:15

COFFEE BREAK

Foyer

  10:15 - 12:15

Clinical Course II: Recurrent pregnancy losses, Rheumatic disease, and immunotherapy

Chair: Joanne Kwak-Kim

 10:15

Aihua Liao, Sina - Treg Cell Senescence in Female Reproductive Potential and Advanced Maternal Pregnancy

 10:45

Joshua Milner, Columbia University - Genetic Disorders of the Immune System II: Windows into Reproductive Immunology?

 11:15

Bonnie Bermas, UT Southwestern - Rheumatic disease and pregnancy management

 11:45

Joanne Kwak-Kim, Rosalind Franklin University - Endometrial gene expressions in women with reproductive failures

  12:15 - 1:15

Clinical Course Lunch Break

  1:15 - 3:15 

Clinical Course III: Infertility and implantation failures

Chair: Rafat Abassi

 1:15

Marcelo Cavalcante, Universidade de Fortaleza - Immunotherapy Guidelines for Laboratory Testing: Open Discussion

 1:45

Mugdha Raut, Dr. Raut's Centre for Reproductive Immunology - Lymphocyte Immunization Therapy (ImmuLIT™) in Recurrent Reproductive Failures (RRF) - The Indian Experience

 2:15

Koji Nakagawa, Sugiyama Clinic Shinjuku - Tacrolimus in Reproductive Failures

 2:45

Abey Eapen, University of Iowa - The Role of Autoimmunity in Reproductive Failure

 3:15 - 3:30 PM

Foyer

Clinical Course IV: Inflammatory immune disorders during pregnancy

Chair: Surendra Sharma & Mohan Raut

Reshef Tal, Yale University - Bone Marrow-derived Progenitors: Contributions to Endometrium and Implications to Recurrent Pregnancy Failure

Babette Lamarca, University of Mississippi - Perinatal TNF-α Blockade May Have Long-Term Positive Effects on Dams and Female Offspring of a Rat Model Preeclampsia

Surendra Sharma, University of Texas Medical Branch - Alzheimer’s Etiology in Younger Population: Lessons from Preeclampsia, A Severe Pregnancy Complication

Karin Fox, University of Texas Medical Branch - Clinical Complications and the role of Placental Immune Activity as a Modulator at the Maternal-Featal Interface

 6:00 - 6:15 PM

Welcome Remarks & Introduction

Ballroom

PL1: CAROLYN COULAM AWARD LECTURE: A journey towards understanding preterm birth, a neonatologists perspective

Liza Konnikova, Yale School of Medicine

2024 Coulam Award recipient

6:45 PM - 8:00 PM

WELCOME RECEPTION

7:00 AM - 4:00 PM

Registration Desk open

 Foyer

7:00 AM - 8:00 AM

Continental Breakfast

 Foyer

8:00 AM - 9:00 AM

PL02: CHAIR'S SESSION: Protective and pathogenic immunity during congenital Zika virus infection

Helen Lazear, UNC Chapel Hill

  Ballroom

9:00 AM - 9:30 AM

AJRI AWARD LECTURE: Exosomal Interleukin -10: A Therapeutic Solution to Preterm Birth?

Ramkumar Menon, UTMB

2024 AJRI Award Recipient

Ballroom

9:30 AM - 10:00 AM

COFFEE BREAK

 Foyer

10:00 AM - 12:00 PM

S-01: A DIFFERENT MATERNAL-FETAL INTERFAE: HOW LACTATION IMPACTS NEONATAL HEALTH AND IMMUNE DEVELOPMENT

Chairs:  Christina Megli (Univ. Pittsburgh) & Brittany Goods (Dartmouth)

Ballroom

10:00

Blair Armistead, Seattle Children's Hospital – Maternal vaccination and infection associated antigen-specific T cells in breastmilk

10:30

Kathryn Knoop, Mayo Clinic - Maternal Protection of Enteric Pathogens

11:00

Deepshika Ramanan, Salk Institute – Got Milk? Role of T cells in Promoting Mammary Immunity and Lactation

11:30

ORAL 01: TBD

11:45

ORAL 02: TBD

10:00 AM - 12:00 PM

S-02:  CYTOMEGALOVIRUS

Chairs:  Craig Bierle & Harsha Palav

Ballroom

10:00

Suresh Boppana, University of Alabama Birmingham – Correlates of Intrauterine Transmission of Cytomegalovirus

10:30

Amitinder Kaur, Tulane University - Insights on vertical transmission bottlenecks in the nonhuman primate model of congenital cytomegalovirus infection

11:00

Joshua Hatterschide, Duke University – Defining cell-intrinsic defenses to herpesvirus infection in trophoblast organoids

11:30

ORAL 03: TBD

11:45

ORAL 04: TBD

12:00 PM - 1:30 PM

LUNCH & LEARN SESSION: CAREER DEVELOPEMENT

Chairs: Sylvie Girard, Elizabeth Enninga, Craig Bierle

Panelists:

• Charu Kaushic, McMaster University
• Sai Majji, NICHD
• Karen Racicot, Quest Diagnostics

1:30 PM - 3:30 PM

S-03: IMMUNE (DYS)REGULATION OF THE ENDOMETRIAL ENVIRONMENT

Chairs: Renate van der Molen & Dorien Feyaerts

Ballroom

1:30

Amy Thees, Rosalind Franklin University – Analysis of Endometrial Gene Expression as an Aid in Management of Recurrent Reproductive Failures

2:00

Renate van der Molen, Radboud UMC – Menstrual blood; from waste to non-invasive immunomonitoring of reproductive health

2:30

Christine Metz, Northwell University – Investigating Menstrual Effluent (ME) to Better Understand the Pathobiology of Endometriosis and to Develop Novel Diagnostic and Treatment Options

3:00

ORAL 05: TBD

3:15

ORAL 06: TBD

1:30 PM - 3:30 PM

S-04: RISK OF CANCER POST-PREGNANCY AND GYNECOLOGICAL CANCER

Chairs:Tiziana Cotechini & Mark Sherman

Ballroom

1:30

Jamie Bakkum-Gamez, Mayo Clinic – Leveraging methylated DNA markers in the detection of endometrial cancer

2:00

Frederic Amant, KU Leuven University – Update on the Management of Cancer During Pregnancy

2:30

Tiziana Cotechini, Queen's University - Pregnancy-induced innate immune reprogramming: implications on postpartum breast cancer progression

3:00

ORAL 07: TBD

3:15

ORAL 08: TBD

3:30 PM – 4:00 PM

COFFEE BREAK

Foyer

3:30 PM – 6:00 PM

POSTER SESSION 

4:00 PM – 5:00 PM

Free Evening - Dinner on your own

7:00 AM - 4:00 PM

Registration Desk open

Foyer

7:00 AM - 8:00 AM

Continental Breakfast

 Foyer

8:00 AM - 9:30 AM

PL03: GUSDON AWARD SESSION

Chairs: TBD

Ballroom

8:00

8:15

G02: TBD

 9:15

G06: TBD

9:30 AM -10:00 AM

COFFEE BREAK

Foyer

10:00 AM - 12:00 PM

S-05: SUBSTANCE ABUSE IN PREGNANCY

Chairs: Heather True & Andrea Edlow

Ballroom

10:15

Heather True, Harvard University – Placental Implications of Maternal Opioid Use With Concurrent Hepatitis C Infection

10:30

Elinor Sullivan, Oregon Health – Kynurenine metabolites mediate the relationship between adiposity during pregnancy and child behavior

11:00

Jamie Lo, Oregon Health Sciences University - Impact of prenatal cannabis exposure on placental and offspring health

11:30

ORAL 09: TBD

11:45

ORAL 10: TBD

10:00 AM - 12:00 PM

S-06: UNDERSTANDING FACTORS THAT INFLUENCE PROTECTION FROM STIs/UTIs AND INTERACTIONS WITH COMMENSALS IN THE REPRODUCTIVE TRACT

Chairs: Amy Gillgrass & Rafael Michita

 Ballroom

10:00

Indira Mysorekar, Baylor College of Medicine – Hormonal and B cell modulation of UTIs in urogenital tract

11:00

Ryan Doster, University of Louisville – Carbohydrates and commensals: metabolic interactions influencing Group B Streptococcus vaginal colonization

11:30

ORAL 11: TBD

11:45

ORAL 12: TBD

12:00 PM - 1:30 PM

ASRI BUSINESS MEETING & LUNCH

Chair: David Aronoff, ASRI President

Ballroom

1:30 PM - 3:30 PM

S-07: TROPHOBLASTS

Chairs:  Tamara Tilburgs & Elizabeth Enninga

Ballrom

1:30

Thor Theunissen, Washington University St. Louis – Building human embryo and placenta models from naive stem cells

2:00

Lynda Harris, University of Nebraska Medical Center – From trophoblast biology to therapeutic interventions

2:30

Kaela Varberg, CMH - Leveraging human trophoblast stem cell models to study placental development

3:00

ORAL 13: TBD

3:15

ORAL 14: TBD

1:30 PM - 3:30 PM

S-08:  REPRODUCTIVE AGING AND IMMUNITY

Chairs:  Aihua Liao & Emilyn Alejandro

Ballroom

1:30

Michael Stout, Oklahoma Medical Research Foundation – Unraveling Cell-Type-Specific Mechanisms of Aging in the Murine Ovary

2:00

Aubrey Converse, Northwestern University - Failed Ovulatory Debris Clearance is Associated with Fibro-Inflammatory Responses in the Aging Ovary

2:30

Yousin Suh, Columbia University – Ovarian Aging: A Target for Geroprotection

3:00

ORAL 15: TBD

3:15

ORAL 16: TBD

3:30 PM - 3:45 PM

COFFEE BREAK

Foyer

3:45 PM – 5:45 PM

S-09: THE COMPLEMENT SYSTEM IN PREGNANCY 

Chairs: Jean Regal & Belen Gimeno-Molina

Ballroom

3:45

Jean Regal, University of Minnesota - The Complement System and Preeclampsia - Preclinical Animal Studies

4:15

Richard Burwick, San Gabriel Valley Perinatal Medical Group, Pomona Valley Medical Center –Complement in Preeclampsia and HELLP Syndrome - Human and Translational Studies

4:45

Lynne Sykes, Imperial College of London – Modulating the cervicovaginal complement response as a therapeutic strategy for preterm birth prevention

5:15

ORAL 17: TBD

5:30

ORAL 18: TBD

3:45 PM – 5:45 PM

S-10: IMMUNOMETABOLISM

Chairs:  Steve McCartney & Eliza McColl

  Ballroom

3:45

Theresa Powell, University of Colorado – Maternal-Placental-Fetal Cross Communication: Metabolic Signals, Nutrients and Exosomes Determine Pregnancy Outcomes and Life-long Health

4:15

Catherine Thornton, Swansea University – Metabolic rewiring of the maternal immune response in pregnancy

4:45

Steve McCartney, University of Washington – Immunometabolism at the Maternal Fetal Interface

5:15

ORAL 19: TBD

5:30

ORAL 20: TBD

7:00 PM - 10:00 PM

TRAINEE NETWORKING EVENT

TBD 

AJRI Editorial Board Meeting (invitation only)

 7:00 AM - 4:00 PM

Registration Desk open

 7:00 AM - 8:00 AM

Continental Breakfast

PL04: PRESIDENT'S SESSION: Advancing Maternal-Child Health through Research: a Perspective from the March of Dimes

Emre Seli, March of Dimes

HERR AWARD LECTURE: 

The vaginal microbiome as a modifier of reproductive health outcomes

David MacIntyre, Imperial College London 

2024 Herr Award recipient

 9:30 AM -10:00 AM

COFFEE BREAK

10:00 AM - 12:00 PM

S-11: FETAL/NEONATAL IMMUNITY

          Chairs: Nathan Schuldt & Tyler Rice

10:30

Amelie Collins, CCHMC – Maternal Inflammation Regulates Fetal Emergency Myelopoiesis

11:00

Naomi McGovern, Cambridge University – Human Placental Macrophages and How They Fight Listeria Monocytogenes Infection

11:30

ORAL 21: TBD

11:45

ORAL 22: TBD

10:00 AM - 12:00 PM

S-12: EV-SPECIFIC IMMUNE IMPACT ON REPRODUCTIVE TISSUES

          Chair: Priya Pantham

10:00

Priya Pantham, UCSD – Placental Extracellular Vesicles as Mediators of Renal Dysfunction in Preeclampsia

10:30

Laura Goetzl, UTHealth Houston - CNS Derived Extracellular Vesicles - Applications to the Perinatal Period

11:00

Lawrence Chamley, University of New Zealand - Placental extracellular vesicles, a therapeutic role in ovarian cancer?

11:30

ORAL 23: TBD

11:45

ORAL 24: TBD

12:00 PM - 1:30 PM

LUNCH & LEARN SESSION: THE VIVIAN ACT AND CMV SCREENING IN MINNESOTA

          Chairs: Sylvie Girard, Craig Bierl & Elizabeth Enninga

Panelists:

• Mark Schleiss, University of Minnesota
• Leah Henrikson
• Stephanie Steidl

1:30 PM - 3:30 PM

S-13: GLYCOIMMUNOLOGY OF PREGNANCY

          Chairs: Wendy Goodman & Petra Lothert

Brian Cobb, Case Western University – Pregnancy-Induced Changes in IgG Function

Gabriela Dveksler, USUHS – Importance of Glycans in the Functions of Human Pregnancy-Specific Glycoproteins

Adrian Erlebacher, UCSF – Glycan Regulation of Fetomaternal Tolerance

ORAL 25: TBD

ORAL 26: TBD

1:30 PM - 3:30 PM

S-14: THERAPEUTIC DEVELOPMENT - VACCINES AND ANTI-INFLAMMATORIES

          Chairs: Natasha Tilston-Lunel & Enrico Barrozo

1:30

Patrick Duffy, NIH – Vaccines for pregnancy malaria—progress and possibilities

2:00

Kristin Adams Waldorf, University of Washington – Impact of an Interleukin-1 Receptor Antagonist on Preterm Labor and Bacterial Trafficking in a Pregnant Nonhuman Primate Model

2:30

Natasha Tilston-Lunel, Indiana University – Establishing a Murine Model to Investigate Vertical Transmission of Oropouche Virus

3:00

ORAL 27: TBD

3:15

ORAL 28: TBD

7:00 PM - 11:00 PM 

ASRI DINNER & AWARDS CEREMONY