11:00 - 12:30

Clinical Course  Examinations

Governors (LL)

ASRI Executive Council Meeting (ASRI Council & Committee Chairs only)

 7:30 - 4:00 

Registration Desk open

Great River Court

 7:00 - 7:50 

Continental Breakfast for Clinical Course attendees

Great River 1

  8:00 - 10:00

Clinical Course I: Laboratory Sciences and Reproductive Failures/ Rheumatology

Chair: Udo Markert

Great River 1

 8:00

CC-01: Mahmood Bilal, Rosalind Franklin University - The role of extrathyroidal compound on immune and endometrial tissue

 8:30

CC-02: Udo Markert, University of Jena - Immunological Aspects of Endometrium

 9:00

CC-03: Theonia Boyd, Texas Children's Hospital - Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology I

CC-04: Theonia Boyd, Texas Children's Hospital -- Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology II

 10:00 - 10:15

COFFEE BREAK

  10:15 - 12:15

Clinical Course II: Recurrent pregnancy losses, Rheumatic disease, and immunotherapy

Chair: Joanne Kwak-Kim

Great River 1

 10:15

CC-05: Aihua Liao, Huazhong University of Science and Technology - Immune Cells and Reproductive Failures

 10:45

CC-06: Rosanna Ramhorst, IQUIBICEN Conicet - The Impact of the Embryonic Quality on Shaping Endometrial Immune Response

 11:15

CC-07: Bonnie Bermas, UT Southwestern - Rheumatic diseases and pregnancy management

 11:45

CC-08: Joanne Kwak-Kim, Rosalind Franklin University - Endometrial gene expressions in women with reproductive failures

  12:15 - 1:15

Clinical Course Lunch Session: Maximize Your Income, Safeguard Your Wealth: Tax Strategies for Clinicians 

Learn proactive, compliant strategies to minimize tax liability, protect your assets, and build lasting wealth—specifically tailored for medical professionals navigating today’s complex financial landscape. Sponsored by Fortune Law Firm

Great River 2

  1:15 - 3:15 

Clinical Course III: Infertility and implantation failures

Chair: Rafat Abassi

Great River 1

 1:15

CC-09: Marcelo Cavalcante, Universidade de Fortaleza - Immunotherapy Guidelines for Laboratory Testing: Open Discussion

 1:45

CC-10: Mugdha Raut, Dr. Raut's Centre for Reproductive Immunology - Lymphocyte Immunization Therapy (ImmuLIT™) in Recurrent Reproductive Failures (RRF) - The Indian Experience

 2:15

CC-11: Koji Nakagawa, Sugiyama Clinic Shinjuku - Tacrolimus in Reproductive Failures

 2:45

CC-12: Abey Eapen, University of Iowa - The Role of Autoimmunity in Reproductive Failure

 3:15 - 3:30

Great River Court

Clinical Course IV: Inflammatory immune disorders during pregnancy

Chair: Surendra Sharma & Mohan Raut

CC-13: Reshef Tal, Yale University - Bone Marrow-derived Progenitors: Contributions to Endometrium and Implications to Recurrent Pregnancy Failure

CC-14: Babette Lamarca, University of Mississippi - Perinatal TNF-α Blockade May Have Long-Term Positive Effects on Dams and Female Offspring of a Rat Model Preeclampsia

CC-15: Surendra Sharma, University of Texas Medical Branch - Alzheimer’s Etiology in Younger Population: Lessons from Preeclampsia, A Severe Pregnancy Complication

CC-16: Karin Fox, University of Texas Medical Branch - Clinical Complications and the role of Placental Immune Activity as a Modulator at the Maternal-Fetal Interface

 6:00 - 6:15

Welcome Remarks & Introduction

Great River 1&4

PL1: CAROLYN COULAM AWARD LECTURE: A Journey Towards Understanding Preterm Birth: A Neonatologists Perspective

Liza Konnikova

Yale School of Medicine

6:45 - 8:00

WELCOME RECEPTION: "ASRI SPEAKEASY"

WANTED: Your presence as we step back in time to the Roaring 20s Prohibition Era in St. Paul, a hideout for gangsters, bank robbers & bootleggers. Put on your "glad rags" and join us - you'll need to show your badge and say the secret password at the door!

Great River

7:00 - 4:00

Registration Desk open

 Great River Court

7:00 - 8:00

Continental Breakfast

Great River Court

8:00 - 9:00

PL02: CHAIR'S SESSION: 

Spatial Relationships Between Antiviral Responses and Zika Virus Infection in a Mouse Model of Congenital Infection

Helen Lazear

University of North Carolina, Chapel Hill

  Great River 1&4

9:00 - 9:30

AJRI AWARD LECTURE: 

Revisiting the Utility of Interleukin-10 using New Approach Methods: Old Wine in a New Bottle

Ramkumar Menon

University of Texas Medical Branch

9:30 - 10:00

COFFEE BREAK

Great River Court

10:00 - 12:00

S-01: A DIFFERENT MATERNAL-FETAL INTERFACE: HOW LACTATION IMPACTS NEONATAL HEALTH AND IMMUNE DEVELOPMENT

Chairs:  Christina Megli & Brittany Goods 

Great River 1

10:00

S-01.1: Blair Armistead, Seattle Children's Hospital – Maternal vaccination and infection associated antigen-specific T cells in breastmilk

10:30

S-01.2: Kathryn Knoop, Mayo Clinic - Maternal Protection of Enteric Pathogens

11:00

S-01.3: Deepshika Ramanan, Salk Institute – Got Milk? Role of T cells in Promoting Mammary Immunity and Lactation

11:30

S-01.4: Mercedes Cassidy, Mayo Clinic - The contribution of T cell dependent mechanisms of B cell activation and differentiation to mammary IgA generation

11:45

S-01.5: Brian Akhapong, University of Minnesota - Impact of Hyperinsulinemia on Mammary Gland Development and Inflammation during Pregnancy

10:00 - 12:00

S-02:  CYTOMEGALOVIRUS

Chairs:  Craig Bierle & Harsha Palav

Great River 4

10:00

S-02.1:Suresh Boppana, University of Alabama Birmingham – Correlates of Intrauterine Transmission of Cytomegalovirus

10:30

S-02.2: Amitinder Kaur, Tulane University - Insights on vertical transmission bottlenecks in the nonhuman primate model of congenital cytomegalovirus infection

11:00

S-02.3: Joshua Hatterschide, Duke University – Defining cell-intrinsic defenses to herpesvirus infection in trophoblast organoids

11:30

S-02.4: Enrico Barrozo, Baylor College of Medicine - Congenital CMV infection shapes fetal immunity via T and B cell clonal expansion

11:45

S-02.5: Harsha Palav, ICMR-National Institute for Research in Reproductive & Child Health, Mumbai - Maternal systemic and HCMV specific cellular immune profiles associated with pregnancy outcomes and congenital transmission in a prospective cohort

12:00 - 1:30

Chairs: Sylvie Girard, Elizabeth Enninga, Craig Bierle

Panelists:  Karen Racicot, Quest Diagnostics, Evann Hilt, University of Minnesota Clinical Microbiology Lab, Ramkumar Menon, Gravitas Womens Health Solutions, Ilana Cohen, UMN Institutional Animal Care and Use Committee

Great River 2&3

1:30 - 3:30

S-03: IMMUNE (DYS)REGULATION OF THE ENDOMETRIAL ENVIRONMENT

Chairs: Renate van der Molen & Dorien Feyaerts

Great River 1

1:30

S-03.1: Amy Thees, Rosalind Franklin University – RNA Targeted Sequencing Aids in the Determination of Genes Associated With Endometrial Dysregulation

2:00

S-03.2: Renate van der Molen, Radboud UMC – Menstrual blood; from waste to non-invasive immunomonitoring of reproductive health

2:30

S-03.3: Christine Metz, Northwell University – Investigating Menstrual Effluent (ME) to Better Understand the Pathobiology of Endometriosis and to Develop Novel Diagnostic and Treatment Options

3:00

S-03.4:  Mona Mohamed, University of Wisconsin-Madison - NK cell trafficking to the decidua is associated with T-bet transcription factor modulation

3:15

S-03.5:  Petra Lothert, Mayo Clinic - IFNγ drives decidual stromal cell dysfunction in villitis of unknown etiology

1:30 - 3:30

S-04: RISK OF CANCER POST-PREGNANCY AND GYNECOLOGICAL CANCER

Chairs:Tiziana Cotechini & Mark Sherman

Great River 4

1:30

S-04.1: Jamie Bakkum-Gamez, Mayo Clinic – Leveraging methylated DNA markers in the detection of endometrial cancer

2:00

S-04.2: Frederic Amant, KU Leuven University – Update on the Management of Cancer During Pregnancy

2:30

S-04.3: Tiziana Cotechini, Queen's University - Pregnancy-induced innate immune reprogramming: implications on postpartum breast cancer progression

3:00

S-04.4: Sarah Nelson, SIU School of Medicine - Assessment of urogenital, gastrointestinal and peritoneal microbiomes in patients with endometrial cancer

3:15

S-04.5: Sneha Mani, University of Pennsylvania - Uterine macrophages and interleukin 1 α and β promote extravillous trophoblast invasion in early pregnancy

3:30 – 4:00

COFFEE BREAK

Great River Court

3:30 – 6:00

POSTER SESSION (All posters: P101-P818)

Great River Court

4:00 – 5:00

TRAINEE NETWORKING EVENT: "The Scholar's Gambit"

New to the game? Make every move count!

Join fellow Trainees for a night of connection, conversation, and a little friendly competition in a relaxed atmosphere at Gambit Brewery. We invite you to play the long game and build lasting professional relationships at this fun event! 

Meet in Lobby @ 6:45

Walk to Gambit Brewery

Free Night / Dinner on your own

7:00 - 4:00

Registration Desk open

Great River Court

7:00 - 8:00

Continental Breakfast

 Great River Court

8:00 - 9:30

PL03: GUSDON AWARD SESSION

Chairs: David Aronoff & Indira Mysorekar

Great River 1&4

8:00

8:15

G-02: Anthony Maxwell, Wayne State University - Prenatal Benzene Exposure Drives Sex-Specific Reprogramming of Pulmonary Immunity in Offspring

 9:15

G-06: Emmanuela Dwomo Agyei - Medical College of Wisconsin - The Role of Neutrophils and Endothelial Cells in the Development of Placental Abruption

9:30 -10:00

COFFEE BREAK

Great River Court

10:00 - 12:00

S-05: SUBSTANCE USE IN PREGNANCY

Chairs: Heather True & Andrea Edlow

Great River 1

10:30

S-05.2: Heather True, University of Kentucky – Maternal opioid use with and without HCV infection disrupts placental structure and immunity 

11:00

S-05.3: Elinor Sullivan, Oregon Health – Kynurenine metabolites mediate the relationship between adiposity during pregnancy and child behavior

11:30

S-05.4 Jamie Lo, Oregon Health Sciences University - Impact of prenatal cannabis exposure on placental and offspring health

10:00 - 12:00

S-06: UNDERSTANDING FACTORS THAT INFLUENCE PROTECTION FROM STIs/UTIs AND INTERACTIONS WITH COMMENSALS IN THE REPRODUCTIVE TRACT

Chairs: Marta Rodriguez-Garcia & Rafael Tomoya Michita

Great River 4

10:00

S-06: Indira Mysorekar, Baylor College of Medicine – Hormonal and B cell modulation of UTIs in urogenital tract

11:00

S-06.3: Ryan Doster, University of Louisville – Carbohydrates and commensals: metabolic interactions influencing Group B Streptococcus vaginal colonization

11:30

S-06.4: Katy Patras, Baylor College of Medicine - Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection

11:45

S-06.5: Sallie Fell, Tulane University - Evaluation of decidual vascularization across gestation in rhesus macaques with and without malaria in pregnancy

12:00 - 1:30

ASRI BUSINESS MEETING & LUNCH 

Chair: David Aronoff

ASRI President

Great River 1&4

Trainees only - RSVP required

Senior members will host discussions at tables with topics that are relatable and of interest to attendees at diverse stages in their careers.

1:30 - 3:30

S-07: TROPHOBLASTS

Chairs:  Tamara Tilburgs & Elizabeth Enninga

Great River 1

1:30

S-07.1: Thor Theunissen, Washington University St. Louis – Building 2D and 3D models of human trophoblast development from naive pluripotent stem cells

2:00

S-07.2: Lynda Harris, University of Nebraska Medical Center – From trophoblast biology to therapeutic interventions

2:30

S-07.3: Kaela Varberg, CMH - Leveraging human trophoblast stem cell models to study placental development

3:00

S-07.4: Sayaka Tsuda, Cincinnati Children's Hospital - Up-regulation of inhibitory molecules on extravillous trophoblasts contributes to immune protection in human pregnancies

3:15

S-07.5: Cynthia McMillen, University of Pittsburgh - Human trophoblasts and placenta explants are susceptible to Oropouche virus infection

1:30 - 3:30

S-08:  REPRODUCTIVE AGING AND IMMUNITY

Chairs:  Aihua Liao & Emilyn Alejandro

Great River 4

1:30

S-08.1: Michael Stout, Oklahoma Medical Research Foundation – Unraveling Cell-Type-Specific Mechanisms of Aging in the Murine Ovary

2:00

S-08.2: Aubrey Converse, Northwestern University - Failed Ovulatory Debris Clearance is Associated with Fibro-Inflammatory Responses in the Aging Ovary

2:30

S-08.3: Aihua Liao, Huazhong University of Science and Technology – Treg Cell Senescence in Female Reproductive Potential and Advanced Maternal Pregnancy

3:00

S-08.4: Elise Sintim-Aboagye, Mayo Clinic - T cells and trophoblasts in villitis of unknown etiology demonstrate unique phenotypic signatures at term compared to preterm

3:15

S-08.5: Fernando Prado Ferreira, Sao Paulo Federal University - Exploring the Interplay Between Advanced Age and Altered Expression of Endometrial Markers: Implications for Relationships

3:30 - 3:45

COFFEE BREAK

Great River Court

3:45 – 5:45

S-09: COMPLEMENT AND ANTI-MICROBIAL FACTORS IN PREGNANCY AND PREGNANCY COMPLICATIONS

Chairs: Jean Regal & Belen Gimeno-Molina

Great River 1

3:45

S-09.1: Jean Regal, University of Minnesota - The Complement System and Preeclampsia - Preclinical Animal Studies

4:15

S-09.2: Richard Burwick, San Gabriel Valley Perinatal Medical Group, Pomona Valley Medical Center –Complement in Preeclampsia and HELLP Syndrome - Human and Translational Studies

4:45

S-09.3: Lynne Sykes, Imperial College of London – Modulating the cervicovaginal complement response as a therapeutic strategy for preterm birth prevention

5:15

S-09.4: Michelle Castillo, Medical College of Wisconsin - Neutrophils drive the formation of Bronchus-Associated Lymphoid Tissue (BALT) and progressive obstetric lung injury in mice with thrombophilia

5:30

S-09.5: Nina Prasanphanich, Cincinnati Children's Hospital - Drivers of antimicrobial functions of decidual natural killer cells in healthy term pregnancy

3:45 – 5:45

S-10: IMMUNOMETABOLISM

Chairs:  Steve McCartney & Eliza McColl

  Great River 4

3:45

S-10.1: Theresa Powell, University of Colorado – Maternal-Placental-Fetal Cross Communication: Metabolic Signals, Nutrients and Exosomes Determine Pregnancy Outcomes and Life-long Health

4:15

S-10.2: Catherine Thornton, Swansea University – Metabolic rewiring of the maternal immune response in pregnancy

4:45

S-10.3: Steve McCartney, University of Washington – Immunometabolism at the Maternal Fetal Interface

5:15

S-10.4: Tracy Her, University of Minnesota - Unlocking the complexity of gestational diabetes mellitus using a physiological model of multiparity  

5:30

S-10.5: Eliza McColl, Baylor College of Medicine - SARS-CoV-2 disrupts iron transport and activates ferroptosis in the human placenta

Free night / dinner on your own

AJRI Editorial Board Meeting (invitation only)

 7:00 - 4:00 

Registration Desk open

Great River Court

 7:00 - 8:00 

Continental Breakfast

Great River Court

PL04: PRESIDENT'S SESSION: 

Advancing Maternal-Child Health through Research: A Perspective from the March of Dimes

Emre Seli

March of Dimes

HERR AWARD LECTURE: 

The vaginal microbiome as a modifier of reproductive health outcomes

David MacIntyre

Imperial College London 

 9:30 -10:00 

COFFEE BREAK

Great River Court

10:00 - 12:00

S-11: FETAL/NEONATAL IMMUNITY

          Chairs: Nathan Schuldt & Tyler Rice

Great River 1

10:30

S-11.2: Amelie Collins, CCHMC – Maternal Inflammation Regulates Fetal Emergency Myelopoiesis

11:00

S-11.3: Naomi McGovern, Cambridge University – Human Placental Macrophages and How They Fight Listeria Monocytogenes Infection

11:30

S-11.4: Tyler Rice, Yale University - Fetal and maternal immune cells in placental villi exhibit dynamic transcriptional responses to both gestational age and complications of pregnancy

11:45

S-11.5: Jacquelyn Lajiness, Indiana University - The Role of IL-9 Signaling in Immune-Mediated Preterm Birth

10:00 - 12:00

S-12: EV-SPECIFIC IMMUNE IMPACT ON REPRODUCTIVE TISSUES

          Chair: Priya Pantham & Hanah Georges

Great River 4

10:00

S-12.1: Priya Pantham, UCSD – Placental Extracellular Vesicles as Mediators of Renal Dysfunction in Preeclampsia

10:30

S-12.2: Laura Goetzl, UTHealth Houston - CNS Derived Extracellular Vesicles - Applications to the Perinatal Period

11:00

S-12.3: Lawrence Chamley, University of New Zealand - Placental extracellular vesicles, a therapeutic role in ovarian cancer?

11:30

S-12.4: Hanah Georges, Yale University - Viral dsRNA triggers fetal membrane-released extracellular vesicles to express elevated TLR7/TLR8-activating microRNAs which sequentially mediate tissue inflammation

11:45

S-12.5: Rafael Tomoya Michita, Baylor College of Medicine - Zika Virus NS1 Induces Tunneling Nanotubes for Vertical Transmission and Disrupts Placental Mitochondrial Function

12:00 PM - 1:30 PM

LW3: THE VIVIAN ACT AND CMV SCREENING IN MINNESOTA

Chairs: Sylvie Girard, Craig Bierl & Elizabeth Enninga

Panelists: Mark Schleiss, University of Minnesota, 

Leah Henrikson and Stephanie Steidl

Great River 2&3

1:30 - 3:30 

S-13: GLYCOIMMUNOLOGY OF PREGNANCY

          Chairs: Wendy Goodman & Petra Lothert

Great River 1

1:30

S-13.1: Brian Cobb, Case Western University – Pregnancy-Induced Changes in IgG Function

2:00

S-13.2: Hai-Bin Ruan, University of Minnesota – Perinatal lymphoid-myeloid balance established by bone marrow stromal O-GlcNAc glycosylation

2:30

S-13.3: Adrian Erlebacher, UCSF – Glycan Regulation of Fetomaternal Tolerance

3:00

S-13.4: Seung-Woo Yang, Kongkuk University, South Korea - Sialylated Immunoglobulin binding to DC-SIGN expressed Hofbauer cells induces its immune tolerable function in the placenta

3:15

S-13.5: Yosuke Ono, University of Yamanashi, Japan- Involvement of anti-β2-glycoprotein I /HLA-DR antibody in recurrent pregnancy loss and adverse obstetric outcomes

1:30 - 3:30 

S-14: THERAPEUTIC DEVELOPMENT - VACCINES AND ANTI-INFLAMMATORIES

          Chairs: Natasha Tilston-Lunel & Enrico Barrozo

Great River 4

1:30

S-14.1: Patrick Duffy, NIH – Vaccines for pregnancy malaria—progress and possibilities:

2:00

S-14.2: Kristin Adams Waldorf, University of Washington – Impact of an Interleukin-1 Receptor Antagonist on Preterm Labor and Bacterial Trafficking in a Pregnant Nonhuman Primate Model

2:30

S-14.3: Natasha Tilston-Lunel, Indiana University – Establishing a Murine Model to Investigate Vertical Transmission of Oropouche Virus

3:00

S-14.4: Jing Luo, Huazhong University of Science and Technology - Macrophage membrane-encapsulated dydrogesterone nanocrystal delivery system: a new strategy for improving the progression of adenomyosis via inhibiting inflammation in uterus

3:15

S-14.5: Austin Hertel, University of Pittsburgh - Protecting mothers and neonates from Rift Valley Fever: RVFV-delNSs/NSm vaccine prevents vertical transmission and neonatal mortality following maternal vaccination

7:00 - 11:00 

ASRI "LAND O'LAKES" DINNER & AWARDS CEREMONY

Uff Da! Celebrate all that is Minnesota - the "Land of 10,000 Lakes" - with this fun evening honoring our scientists and embracing the rich heritage of this state.

After dinner & awards, you betcha we'll open up the dance floor! 

Great River 2&3