The American Society forReproductive Immunology |
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Saturday, May 17
11:00 - 12:30 |
Clinical Course Examinations |
Governors (LL) |
2:00 - 3:30 | FCRI Board Meeting | Governors (LL) |
4:30 - 6:30 | Registration Desk Open | Main Lobby |
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5:00 - 6:30 |
ASRI Executive Council Meeting (ASRI Council & Committee Chairs only) |
State Suite (LL) |
7:30 - 4:00 |
Registration Desk open |
Great River Court |
7:00 - 7:50 |
Continental Breakfast for Clinical Course attendees |
Great River 1 |
7:50 - 8:00 | Clinical Course Welcome & Introduction | Great River 1 |
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Clinical Course I: Laboratory Sciences and Reproductive Failures/ Rheumatology Chair: Udo Markert |
Great River 1 |
8:00 |
CC-01: Mahmood Bilal, Rosalind Franklin University - The role of extrathyroidal compound on immune and endometrial tissue |
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8:30 |
CC-02: Udo Markert, University of Jena - Immunological Aspects of Endometrium |
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9:00 |
CC-03: Theonia Boyd, Texas Children's Hospital - Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology I |
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9:30 |
CC-04: Theonia Boyd, Texas Children's Hospital -- Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology II |
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10:00 - 10:15 |
COFFEE BREAK |
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Clinical Course II: Recurrent pregnancy losses, Rheumatic disease, and immunotherapy Chair: Joanne Kwak-Kim |
Great River 1 |
10:15 |
CC-05: Aihua Liao, Huazhong University of Science and Technology - Treg Cell Senescence in Female Reproductive Potential and Advanced Maternal Pregnancy |
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10:45 |
CC-06: Rosanna Ramhorst - The Impact of the Embryonic Quality on Shaping Endometrial Immune Response |
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11:15 |
CC-07: Bonnie Bermas, UT Southwestern - Rheumatic disease and pregnancy management |
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11:45 |
CC-08: Joanne Kwak-Kim, Rosalind Franklin University - Endometrial gene expressions in women with reproductive failures |
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Clinical Course Lunch Break |
on your own |
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Clinical Course III: Infertility and implantation failures Chair: Rafat Abassi |
Great River 1 |
1:15 |
CC-09: Marcelo Cavalcante, Universidade de Fortaleza - Immunotherapy Guidelines for Laboratory Testing: Open Discussion |
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1:45 |
CC-10: Mugdha Raut, Dr. Raut's Centre for Reproductive Immunology - Lymphocyte Immunization Therapy (ImmuLIT™) in Recurrent Reproductive Failures (RRF) - The Indian Experience |
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2:15 |
CC-11: Koji Nakagawa, Sugiyama Clinic Shinjuku - Tacrolimus in Reproductive Failures |
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2:45 |
CC-12: Abey Eapen, University of Iowa - The Role of Autoimmunity in Reproductive Failure |
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3:15 - 3:30 |
COFFEE BREAK |
Great River Court |
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Clinical Course IV: Inflammatory immune disorders during pregnancy Chair: Surendra Sharma & Mohan Raut |
Great River 1 |
3:30 |
CC-13: Reshef Tal, Yale University - Bone Marrow-derived Progenitors: Contributions to Endometrium and Implications to Recurrent Pregnancy Failure |
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4:00 |
CC-14: Babette Lamarca, University of Mississippi - Perinatal TNF-α Blockade May Have Long-Term Positive Effects on Dams and Female Offspring of a Rat Model Preeclampsia |
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4:30 |
CC-15: Surendra Sharma, University of Texas Medical Branch - Alzheimer’s Etiology in Younger Population: Lessons from Preeclampsia, A Severe Pregnancy Complication |
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5:00 |
CC-16: Karin Fox, University of Texas Medical Branch - Clinical Complications and the role of Placental Immune Activity as a Modulator at the Maternal-Featal Interface |
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5:30 - 6:00 | BREAK | Great River Court |
6:00 - 6:15 |
Welcome Remarks & Introduction |
Great River 1&4 |
6:15 - 6:45 |
Liza Konnikova Yale School of Medicine |
Great River 1&4 |
6:45 - 8:00 |
WANTED: Your presence as we step back in time to the Roaring 20s Prohibition Era in St. Paul, a hideout for gangsters, bank robbers & bootleggers. Put on your "glad rags" and join us - you'll need to show your badge and say the secret password at the door! |
Great River |
7:00 - 4:00 |
Registration Desk open |
Great River Court |
7:00 - 8:00 |
Continental Breakfast |
Great River Court |
8:00 - 9:00 |
![]() PL02: CHAIR'S SESSION: Spatial Relationships Between Antiviral Responses and Zika Virus Infection in a Mouse Model of Congenital Infection Helen Lazear University of North Carolina, Chapel Hill |
Great River 1&4 |
9:00 - 9:30 |
Revisiting the Utility of Interleukin-10 using New Approach Methods: Old Wine in a New Bottle Ramkumar Menon University of Texas Medical Branch |
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9:30 - 10:00 |
COFFEE BREAK |
Great River Court |
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10:00 - 12:00 |
S-01: A DIFFERENT MATERNAL-FETAL INTERFACE: HOW LACTATION IMPACTS NEONATAL HEALTH AND IMMUNE DEVELOPMENT Chairs: Christina Megli & Brittany Goods |
Great River 1 |
10:00 |
S-01.1: Blair Armistead, Seattle Children's Hospital – Maternal vaccination and infection associated antigen-specific T cells in breastmilk |
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10:30 |
S-01.2: Kathryn Knoop, Mayo Clinic - Maternal Protection of Enteric Pathogens |
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11:00 |
S-01.3: Deepshika Ramanan, Salk Institute – Got Milk? Role of T cells in Promoting Mammary Immunity and Lactation |
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11:30 |
S-01.4: Elisha Segrist, NIH -The cervicovaginal microbiota regulates uterine cellular immunity via endogenous retroelements and type 3 interferons |
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11:45 |
S-01.5: Brian Akhapong, University of Minnesota - Impact of Hyperinsulinemia on Mammary Gland Development and Inflammation during Pregnancy |
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10:00 - 12:00 |
S-02: CYTOMEGALOVIRUS Chairs: Craig Bierle & Harsha Palav |
Great River 4 |
10:00 |
S-02.1:Suresh Boppana, University of Alabama Birmingham – Correlates of Intrauterine Transmission of Cytomegalovirus |
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10:30 |
S-02.2: Amitinder Kaur, Tulane University - Insights on vertical transmission bottlenecks in the nonhuman primate model of congenital cytomegalovirus infection |
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11:00 |
S-02.3: Joshua Hatterschide, Duke University – Defining cell-intrinsic defenses to herpesvirus infection in trophoblast organoids |
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11:30 |
S-02.4: Enrico Barrozo, Baylor College of Medicine - Congenital CMV infection shapes fetal immunity via T and B cell clonal expansion |
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11:45 |
S-02.5: Harsha Palav, ICMR-National Institute for Research in Reproductive & Child Health, Mumbai - Maternal systemic and HCMV specific cellular immune profiles associated with pregnancy outcomes and congenital transmission in a prospective cohort |
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12:00 - 1:30 |
Chairs: Sylvie Girard, Elizabeth Enninga, Craig Bierle Panelists: Charu Kaushic, McMaster University, Sai Majji, NICHD, and Karen Racicot, Quest Diagnostics |
Great River 2&3
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1:30 - 3:30 |
S-03: IMMUNE (DYS)REGULATION OF THE ENDOMETRIAL ENVIRONMENT Chairs: Renate van der Molen & Dorien Feyaerts |
Great River 1 |
1:30 |
S-03.1: Amy Thees, Rosalind Franklin University – RNA Targeted Sequencing Aids in the Determination of Genes Associated With Endometrial Dysregulation |
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2:00 |
S-03.2: Renate van der Molen, Radboud UMC – Menstrual blood; from waste to non-invasive immunomonitoring of reproductive health |
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2:30 |
S-03.3: Christine Metz, Northwell University – Investigating Menstrual Effluent (ME) to Better Understand the Pathobiology of Endometriosis and to Develop Novel Diagnostic and Treatment Options |
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3:00 |
S-03.4: Mona Mohamed, University of Wisconsin-Madison - NK cell trafficking to the decidua is associated with T-bet transcription factor modulation |
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3:15 |
S-03.5: Petra Lothert, Mayo Clinic - IFNγ drives decidual stromal cell dysfunction in villitis of unknown etiology |
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1:30 - 3:30 |
S-04: RISK OF CANCER POST-PREGNANCY AND GYNECOLOGICAL CANCER Chairs:Tiziana Cotechini & Mark Sherman |
Great River 4 |
1:30 |
S-04.1: Jamie Bakkum-Gamez, Mayo Clinic – Leveraging methylated DNA markers in the detection of endometrial cancer |
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2:00 |
S-04.2: Frederic Amant, KU Leuven University – Update on the Management of Cancer During Pregnancy |
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2:30 |
S-04.3: Tiziana Cotechini, Queen's University - Pregnancy-induced innate immune reprogramming: implications on postpartum breast cancer progression |
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3:00 |
S-04.4: Sarah Nelson, SIU School of Medicine - Assessment of urogenital, gastrointestinal and peritoneal microbiomes in patients with endometrial cancer |
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3:15 |
S-04.5: Sneha Mani, University of Pennsylvania - Uterine macrophages and interleukin 1 α and β promote extravillous trophoblast invasion in early pregnancy |
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3:30 – 4:00 |
COFFEE BREAK |
Great River Court |
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3:30 – 6:00 |
POSTER SESSION (All posters: P101-P818) |
Great River Court |
4:00 – 5:00 |
POSTER JUDGING (Top Poster Finalists) |
Great River Court |
7:00 - 9:00 |
New to the game? Make every move count! Join fellow Trainees for a night of connection, conversation, and a little friendly competition in a relaxed atmosphere at Gambit Brewery. We invite you to play the long game and build lasting professional relationships at this fun event! |
Meet in Lobby @ 6:45 Walk to Gambit Brewery |
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Free Night / Dinner on your own |
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7:00 - 4:00 |
Registration Desk open |
Great River Court |
7:00 - 8:00 |
Continental Breakfast |
Great River Court |
8:00 - 9:30 |
Chair: David Aronoff |
Great River 1&4 |
8:00 |
G-01: Jessica Weng, Mayo Clinic - Placental macrophages and prenatal inflammation at the placenta | |
8:15 |
G-02: Anthony Maxwell, Wayne State University - Prenatal Benzene Exposure Drives Sex-Specific Reprogramming of Pulmonary Immunity in Offspring |
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8:30 | G-03: Aleah Holmes, Tufts University - Tissue Senescence and its Role in Neutrophil-Mediated Protection Against HIV in The Aging Female Genital Tract | |
8:45 | G-04: Jennifer Wayland - University of Cincinnati - Modeling vertical transmission of obesity-associated immunopathogenic traits in mice |
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9:00 | G-05: Fabienne Hanton - Imperial College London - Bacterial metabolites mediate vaginal epithelial cell inflammation via pro-inflammatory transcription factor inhibition |
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9:15 |
G-06: Emmanuela Dwomo Agyei - Medical College of Wisconsin - The Role of Neutrophils and Endothelial Cells in the Development of Placental Abruption |
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9:30 -10:00 |
COFFEE BREAK |
Great River Court |
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10:00 - 12:00 |
S-05: SUBSTANCE ABUSE IN PREGNANCY Chairs: Heather True & Andrea Edlow |
Great River 1 |
10:00 | S-05.1: Andrea Edlow, Harvard University - Substance Use in Pregnancy: Maternal and Fetoplacental Immune Impact | |
10:30 |
S-05.2: Heather True, University of Kentucky – Maternal opioid use with and without HCV infection disrupts placental structure and immunity |
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11:00 |
S-05.3: Elinor Sullivan, Oregon Health – Kynurenine metabolites mediate the relationship between adiposity during pregnancy and child behavior |
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11:30 |
S-05.4 Jamie Lo, Oregon Health Sciences University - Impact of prenatal cannabis exposure on placental and offspring health |
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10:00 - 12:00 |
S-06: UNDERSTANDING FACTORS THAT INFLUENCE PROTECTION FROM STIs/UTIs AND INTERACTIONS WITH COMMENSALS IN THE REPRODUCTIVE TRACT Chairs: Amy Gillgrass & Rafael Michita |
Great River 4 |
10:00 |
S-06: Indira Mysorekar, Baylor College of Medicine – Hormonal and B cell modulation of UTIs in urogenital tract |
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10:30 | S-06.2: Jennifer Lund, Fred Hutch - Regulation of immunity in the female genital tract in context of virus infection |
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11:00 |
S-06.3: Ryan Doster, University of Louisville – Carbohydrates and commensals: metabolic interactions influencing Group B Streptococcus vaginal colonization |
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11:30 |
S-06.4: Katy Patras, Baylor College of Medicine - Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection |
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11:45 |
S-06.5: Sallie Fell, Tulane University - Evaluation of decidual vascularization across gestation in rhesus macaques with and without malaria in pregnancy |
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12:00 PM - 1:30 PM |
Chair: David Aronoff ASRI President |
Great River 1&4 |
12:00 - 1:30 |
Trainees only - RSVP required |
Great River 2 |
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1:30 - 3:30 |
S-07: TROPHOBLASTS Chairs: Tamara Tilburgs & Elizabeth Enninga |
Great River 1 |
1:30 |
S-07.1: Thor Theunissen, Washington University St. Louis – Building human embryo and placenta models from naive stem cells |
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2:00 |
S-07.2: Lynda Harris, University of Nebraska Medical Center – From trophoblast biology to therapeutic interventions |
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2:30 |
S-07.3: Kaela Varberg, CMH - Leveraging human trophoblast stem cell models to study placental development |
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3:00 |
S-07.4: Sayaka Tsuda, Cincinnati Children's Hospital - Up-regulation of inhibitory molecules on extravillous trophoblasts contributes to immune protection in human pregnancies |
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3:15 |
S-07.5: Cynthia McMillen, University of Pittsburgh - Human trophoblasts and placenta explants are susceptible to Oropouche virus infection |
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1:30 - 3:30 |
S-08: REPRODUCTIVE AGING AND IMMUNITY Chairs: Aihua Liao & Emilyn Alejandro |
Great River 4 |
1:30 |
S-08.1: Michael Stout, Oklahoma Medical Research Foundation – Unraveling Cell-Type-Specific Mechanisms of Aging in the Murine Ovary |
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2:00 |
S-08.2: Aubrey Converse, Northwestern University - Failed Ovulatory Debris Clearance is Associated with Fibro-Inflammatory Responses in the Aging Ovary |
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2:30 |
S-08.3: Yousin Suh, Columbia University – Ovarian Aging: A Target for Geroprotection |
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3:00 |
S-08.4: Rupesh Srivastava, All India Instutite of Medical Sciences (AIMS) - Therapeutic Targeting of Osteoclastogenic Th9 Cells : A Novel Approach to Combat Inflammatory Bone Loss in Postmenopausal Osteoporosis |
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3:15 |
S-08.5: Fernando Prado Ferreira, Sao Paulo Federal University - Exploring the Interplay Between Advanced Age and Altered Expression of Endometrial Markers: Implications for Relationships |
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3:30 - 3:45 |
COFFEE BREAK |
Great River Court |
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3:45 – 5:45 |
S-09: COMPLEMENT AND ANTI-MICROBIAL FACTORS IN PREGNANCY AND PREGNANCY COMPLICATIONS Chairs: Jean Regal & Belen Gimeno-Molina |
Great River 1 |
3:45 |
S-09.1: Jean Regal, University of Minnesota - The Complement System and Preeclampsia - Preclinical Animal Studies |
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4:15 |
S-09.2: Richard Burwick, San Gabriel Valley Perinatal Medical Group, Pomona Valley Medical Center –Complement in Preeclampsia and HELLP Syndrome - Human and Translational Studies |
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4:45 |
S-09.3: Lynne Sykes, Imperial College of London – Modulating the cervicovaginal complement response as a therapeutic strategy for preterm birth prevention |
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5:15 |
S-09.4: Michelle Castillo, Medical College of Wisconsin - Neutrophils drive the formation of Bronchus-Associated Lymphoid Tissue (BALT) and progressive obstetric lung injury in mice with thrombophilia |
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5:30 |
S-09.5: Nina Prasanphanich, Cincinnati Children's Hospital - Drivers of antimicrobial functions of decidual natural killer cells in healthy term pregnancy |
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3:45 – 5:45 |
S-10: IMMUNOMETABOLISM Chairs: Steve McCartney & Eliza McColl |
Great River 4 |
3:45 |
S-10.1: Theresa Powell, University of Colorado – Maternal-Placental-Fetal Cross Communication: Metabolic Signals, Nutrients and Exosomes Determine Pregnancy Outcomes and Life-long Health |
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4:15 |
S-10.2: Catherine Thornton, Swansea University – Metabolic rewiring of the maternal immune response in pregnancy |
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4:45 |
S-10.3: Steve McCartney, University of Washington – Immunometabolism at the Maternal Fetal Interface |
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5:15 |
S-10.4: Tracy Her, University of Minnesota - Unlocking the complexity of gestational diabetes mellitus using a physiological model of multiparity |
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5:30 |
S-10.5: Eliza McColl, Baylor College of Medicine - SARS-CoV-2 disrupts iron transport and activates ferroptosis in the human placenta |
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Free night / dinner on your own |
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7:00 - 9:00 |
AJRI Editorial Board Meeting (invitation only) |
7:00 - 4:00 |
Registration Desk open |
Great River Court |
7:00 - 8:00 |
Continental Breakfast |
Great River Court |
8:00 - 9:00 |
Advancing Maternal-Child Health through Research: A Perspective from the March of Dimes Emre Seli March of Dimes |
Great River 1&4 |
9:00 - 9:30 |
The vaginal microbiome as a modifier of reproductive health outcomes David MacIntyre Imperial College London |
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9:30 -10:00 |
COFFEE BREAK |
Great River Court |
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10:00 - 12:00 |
S-11: FETAL/NEONATAL IMMUNITY Chairs: Nathan Schuldt & Tyler Rice |
Great River 1 |
10:00 | S-11.1: Nathan Schuldt - University of Minnesota - Physiological Microbial Exposure and Fetal Immune Development | |
10:30 |
S-11.2: Amelie Collins, CCHMC – Maternal Inflammation Regulates Fetal Emergency Myelopoiesis |
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11:00 |
S-11.3: Naomi McGovern, Cambridge University – Human Placental Macrophages and How They Fight Listeria Monocytogenes Infection |
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11:30 |
S-11.4: Tyler Rice, Yale University - Fetal and maternal immune cells in placental villi exhibit dynamic transcriptional responses to both gestational age and complications of pregnancy |
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11:45 |
S-11.5: Jacquelyn Lajiness, Indiana University - Investigating immunological changes at the feto-maternal interface in a murine model of placental abruption |
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10:00 - 12:00 |
S-12: EV-SPECIFIC IMMUNE IMPACT ON REPRODUCTIVE TISSUES Chair: Priya Pantham |
Great River 4 |
10:00 |
S-12.1: Priya Pantham, UCSD – Placental Extracellular Vesicles as Mediators of Renal Dysfunction in Preeclampsia |
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10:30 |
S-12.2:Laura Goetzl, UTHealth Houston - CNS Derived Extracellular Vesicles - Applications to the Perinatal Period |
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11:00 |
S-12.3:Lawrence Chamley, University of New Zealand - Placental extracellular vesicles, a therapeutic role in ovarian cancer? |
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11:30 |
S-12.4: Hanah Georges, Yale University - Viral dsRNA triggers fetal membrane-released extracellular vesicles to express elevated TLR7/TLR8-activating microRNAs which sequentially mediate tissue inflammation |
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11:45 |
S-12.5: Rafael Tomoya Michita, Baylor College of Medicine - Zika Virus NS1 Induces Tunneling Nanotubes for Vertical Transmission and Disrupts Placental Mitochondrial Function |
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12:00 PM - 1:30 PM |
LW3: THE VIVIAN ACT AND CMV SCREENING IN MINNESOTA Chairs: Sylvie Girard, Craig Bierl & Elizabeth Enninga
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1:30 - 3:30 |
S-13: GLYCOIMMUNOLOGY OF PREGNANCY Chairs: Wendy Goodman & Petra Lothert |
Great River 1 |
1:30 |
S-13.1: Brian Cobb, Case Western University – Pregnancy-Induced Changes in IgG Function |
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2:00 |
S-13.2: Gabriela Dveksler, USUHS – Importance of Glycans in the Functions of Human Pregnancy-Specific Glycoproteins |
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2:30 |
S-13.3: Adrian Erlebacher, UCSF – Glycan Regulation of Fetomaternal Tolerance |
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3:00 |
S-13.4: Seung-Woo Yang, Kongkuk University, South Korea - Sialylated Immunoglobulin binding to DC-SIGN expressed Hofbauer cells induces its immune tolerable function in the placenta |
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3:15 |
S-13.5: Yosuke Ono, University of Yamanashi, Japan- Involvement of anti-β2-glycoprotein I /HLA-DR antibody in recurrent pregnancy loss and adverse obstetric outcomes |
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1:30 - 3:30 |
S-14: THERAPEUTIC DEVELOPMENT - VACCINES AND ANTI-INFLAMMATORIES Chairs: Natasha Tilston-Lunel & Enrico Barrozo |
Great River 4 |
1:30 |
S-14.1: Patrick Duffy, NIH – Vaccines for pregnancy malaria—progress and possibilities: |
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2:00 |
S-14.2: Kristin Adams Waldorf, University of Washington – Impact of an Interleukin-1 Receptor Antagonist on Preterm Labor and Bacterial Trafficking in a Pregnant Nonhuman Primate Model |
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2:30 |
S-14.3: Natasha Tilston-Lunel, Indiana University – Establishing a Murine Model to Investigate Vertical Transmission of Oropouche Virus |
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3:00 |
S-14.4: Jing Luo, Huazhong University of Science and Technology - Macrophage membrane-encapsulated dydrogesterone nanocrystal delivery system: a new strategy for improving the progression of adenomyosis via inhibiting inflammation in uterus |
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3:15 |
S-14.5: Austin Hertel, University of Pittsburgh - Protecting mothers and neonates from Rift Valley Fever: RVFV-delNSs/NSm vaccine prevents vertical transmission and neonatal mortality following maternal vaccination |
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3:30 - 7:00 | Free Time / on your own | |
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7:00 - 11:00 |
Uff Da! Celebrate all that is Minnesota - the "Land of 10,000 Lakes" - with this fun evening honoring our scientists and embracing the rich heritage of this state. After dinner & awards, you betcha we'll open up the dance floor! |
Great River 2&3 |
Thursday, May 22
AM | Departures |