11:00 - 12:30

Clinical Course  Examinations

Governors (LL)

ASRI Executive Council Meeting (ASRI Council & Committee Chairs only)

 7:30 - 4:00 

Registration Desk open

Great River Court

 7:00 - 7:50 

Continental Breakfast for Clinical Course attendees

Great River 1

  8:00 - 10:00

Clinical Course I: Laboratory Sciences and Reproductive Failures/ Rheumatology

Chair: Udo Markert

Great River 1

 8:00

CC-01: Mahmood Bilal, Rosalind Franklin University - The role of extrathyroidal compound on immune and endometrial tissue

 8:30

CC-02: Udo Markert, University of Jena - Immunological Aspects of Endometrium

 9:00

CC-03: Theonia Boyd, Texas Children's Hospital - Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology I

CC-04: Theonia Boyd, Texas Children's Hospital -- Immunologic Mechanisms of Pregnancy Loss Throughout Gestation: Placental Pathology II

 10:00 - 10:15

COFFEE BREAK

  10:15 - 12:15

Clinical Course II: Recurrent pregnancy losses, Rheumatic disease, and immunotherapy

Chair: Joanne Kwak-Kim

Great River 1

 10:15

CC-05: Aihua Liao, Huazhong University of Science and Technology - Immune Cells and Reproductive Failures

 10:45

CC-06: Rosanna Ramhorst, IQUIBICEN Conicet - The Impact of the Embryonic Quality on Shaping Endometrial Immune Response

 11:15

CC-07: Bonnie Bermas, UT Southwestern - Rheumatic disease and pregnancy management

 11:45

CC-08: Joanne Kwak-Kim, Rosalind Franklin University - Endometrial gene expressions in women with reproductive failures

  12:15 - 1:15

Clinical Course Lunch Break

on your own

  1:15 - 3:15 

Clinical Course III: Infertility and implantation failures

Chair: Rafat Abassi

Great River 1

 1:15

CC-09: Marcelo Cavalcante, Universidade de Fortaleza - Immunotherapy Guidelines for Laboratory Testing: Open Discussion

 1:45

CC-10: Mugdha Raut, Dr. Raut's Centre for Reproductive Immunology - Lymphocyte Immunization Therapy (ImmuLIT™) in Recurrent Reproductive Failures (RRF) - The Indian Experience

 2:15

CC-11: Koji Nakagawa, Sugiyama Clinic Shinjuku - Tacrolimus in Reproductive Failures

 2:45

CC-12: Abey Eapen, University of Iowa - The Role of Autoimmunity in Reproductive Failure

 3:15 - 3:30

Great River Court

Clinical Course IV: Inflammatory immune disorders during pregnancy

Chair: Surendra Sharma & Mohan Raut

CC-13: Reshef Tal, Yale University - Bone Marrow-derived Progenitors: Contributions to Endometrium and Implications to Recurrent Pregnancy Failure

CC-14: Babette Lamarca, University of Mississippi - Perinatal TNF-α Blockade May Have Long-Term Positive Effects on Dams and Female Offspring of a Rat Model Preeclampsia

CC-15: Surendra Sharma, University of Texas Medical Branch - Alzheimer’s Etiology in Younger Population: Lessons from Preeclampsia, A Severe Pregnancy Complication

CC-16: Karin Fox, University of Texas Medical Branch - Clinical Complications and the role of Placental Immune Activity as a Modulator at the Maternal-Featal Interface

 6:00 - 6:15

Welcome Remarks & Introduction

Great River 1&4

PL1: CAROLYN COULAM AWARD LECTURE: A Journey Towards Understanding Preterm Birth: A Neonatologists Perspective

Liza Konnikova

Yale School of Medicine

6:45 - 8:00

WELCOME RECEPTION: "ASRI SPEAKEASY"

WANTED: Your presence as we step back in time to the Roaring 20s Prohibition Era in St. Paul, a hideout for gangsters, bank robbers & bootleggers. Put on your "glad rags" and join us - you'll need to show your badge and say the secret password at the door!

Great River

7:00 - 4:00

Registration Desk open

 Great River Court

7:00 - 8:00

Continental Breakfast

Great River Court

8:00 - 9:00

PL02: CHAIR'S SESSION: 

Spatial Relationships Between Antiviral Responses and Zika Virus Infection in a Mouse Model of Congenital Infection

Helen Lazear

University of North Carolina, Chapel Hill

  Great River 1&4

9:00 - 9:30

AJRI AWARD LECTURE: 

Revisiting the Utility of Interleukin-10 using New Approach Methods: Old Wine in a New Bottle

Ramkumar Menon

University of Texas Medical Branch

9:30 - 10:00

COFFEE BREAK

Great River Court

10:00 - 12:00

S-01: A DIFFERENT MATERNAL-FETAL INTERFACE: HOW LACTATION IMPACTS NEONATAL HEALTH AND IMMUNE DEVELOPMENT

Chairs:  Christina Megli & Brittany Goods 

Great River 1

10:00

S-01.1: Blair Armistead, Seattle Children's Hospital – Maternal vaccination and infection associated antigen-specific T cells in breastmilk

10:30

S-01.2: Kathryn Knoop, Mayo Clinic - Maternal Protection of Enteric Pathogens

11:00

S-01.3: Deepshika Ramanan, Salk Institute – Got Milk? Role of T cells in Promoting Mammary Immunity and Lactation

11:30

S-01.4: Christina Megli -TBD

11:45

S-01.5: Brian Akhapong, University of Minnesota - Impact of Hyperinsulinemia on Mammary Gland Development and Inflammation during Pregnancy

10:00 - 12:00

S-02:  CYTOMEGALOVIRUS

Chairs:  Craig Bierle & Harsha Palav

Great River 4

10:00

S-02.1:Suresh Boppana, University of Alabama Birmingham – Correlates of Intrauterine Transmission of Cytomegalovirus

10:30

S-02.2: Amitinder Kaur, Tulane University - Insights on vertical transmission bottlenecks in the nonhuman primate model of congenital cytomegalovirus infection

11:00

S-02.3: Joshua Hatterschide, Duke University – Defining cell-intrinsic defenses to herpesvirus infection in trophoblast organoids

11:30

S-02.4: Enrico Barrozo, Baylor College of Medicine - Congenital CMV infection shapes fetal immunity via T and B cell clonal expansion

11:45

S-02.5: Harsha Palav, ICMR-National Institute for Research in Reproductive & Child Health, Mumbai - Maternal systemic and HCMV specific cellular immune profiles associated with pregnancy outcomes and congenital transmission in a prospective cohort

12:00 - 1:30

Chairs: Sylvie Girard, Elizabeth Enninga, Craig Bierle

Panelists:  Karen Racicot, Quest Diagnostics, Evann Hilt, University of Minnesota Clinical Microbiology Lab, Ramkumar Menon, Gravitas Womens Health Services, Ilana Cohen, UMN Institutional Animal Care and Use Committee

Great River 2&3

1:30 - 3:30

S-03: IMMUNE (DYS)REGULATION OF THE ENDOMETRIAL ENVIRONMENT

Chairs: Renate van der Molen & Dorien Feyaerts

Great River 1

1:30

S-03.1: Amy Thees, Rosalind Franklin University – RNA Targeted Sequencing Aids in the Determination of Genes Associated With Endometrial Dysregulation

2:00

S-03.2: Renate van der Molen, Radboud UMC – Menstrual blood; from waste to non-invasive immunomonitoring of reproductive health

2:30

S-03.3: Christine Metz, Northwell University – Investigating Menstrual Effluent (ME) to Better Understand the Pathobiology of Endometriosis and to Develop Novel Diagnostic and Treatment Options

3:00

S-03.4:  Mona Mohamed, University of Wisconsin-Madison - NK cell trafficking to the decidua is associated with T-bet transcription factor modulation

3:15

S-03.5:  Petra Lothert, Mayo Clinic - IFNγ drives decidual stromal cell dysfunction in villitis of unknown etiology

1:30 - 3:30

S-04: RISK OF CANCER POST-PREGNANCY AND GYNECOLOGICAL CANCER

Chairs:Tiziana Cotechini & Mark Sherman

Great River 4

1:30

S-04.1: Jamie Bakkum-Gamez, Mayo Clinic – Leveraging methylated DNA markers in the detection of endometrial cancer

2:00

S-04.2: Frederic Amant, KU Leuven University – Update on the Management of Cancer During Pregnancy

2:30

S-04.3: Tiziana Cotechini, Queen's University - Pregnancy-induced innate immune reprogramming: implications on postpartum breast cancer progression

3:00

S-04.4: Sarah Nelson, SIU School of Medicine - Assessment of urogenital, gastrointestinal and peritoneal microbiomes in patients with endometrial cancer

3:15

S-04.5: Sneha Mani, University of Pennsylvania - Uterine macrophages and interleukin 1 α and β promote extravillous trophoblast invasion in early pregnancy

3:30 – 4:00

COFFEE BREAK

Great River Court

3:30 – 6:00

POSTER SESSION (All posters: P101-P818)

Great River Court

4:00 – 5:00

TRAINEE NETWORKING EVENT: "The Scholar's Gambit"

New to the game? Make every move count!

Join fellow Trainees for a night of connection, conversation, and a little friendly competition in a relaxed atmosphere at Gambit Brewery. We invite you to play the long game and build lasting professional relationships at this fun event! 

Meet in Lobby @ 6:45

Walk to Gambit Brewery

Free Night / Dinner on your own

7:00 - 4:00

Registration Desk open

Great River Court

7:00 - 8:00

Continental Breakfast

 Great River Court

8:00 - 9:30

PL03: GUSDON AWARD SESSION

Chairs: David Aronoff & Indira Mysorekar

Great River 1&4

8:00

8:15

G-02: Anthony Maxwell, Wayne State University - Prenatal Benzene Exposure Drives Sex-Specific Reprogramming of Pulmonary Immunity in Offspring

 9:15

G-06: Emmanuela Dwomo Agyei - Medical College of Wisconsin - The Role of Neutrophils and Endothelial Cells in the Development of Placental Abruption

9:30 -10:00

COFFEE BREAK

Great River Court

10:00 - 12:00

S-05: SUBSTANCE ABUSE IN PREGNANCY

Chairs: Heather True & Andrea Edlow

Great River 1

10:30

S-05.2: Heather True, University of Kentucky – Maternal opioid use with and without HCV infection disrupts placental structure and immunity 

11:00

S-05.3: Elinor Sullivan, Oregon Health – Kynurenine metabolites mediate the relationship between adiposity during pregnancy and child behavior

11:30

S-05.4 Jamie Lo, Oregon Health Sciences University - Impact of prenatal cannabis exposure on placental and offspring health

10:00 - 12:00

S-06: UNDERSTANDING FACTORS THAT INFLUENCE PROTECTION FROM STIs/UTIs AND INTERACTIONS WITH COMMENSALS IN THE REPRODUCTIVE TRACT

Chairs: Marta Rodriguez-Garcia & Rafael Tomoya Michita

Great River 4

10:00

S-06: Indira Mysorekar, Baylor College of Medicine – Hormonal and B cell modulation of UTIs in urogenital tract

11:00

S-06.3: Ryan Doster, University of Louisville – Carbohydrates and commensals: metabolic interactions influencing Group B Streptococcus vaginal colonization

11:30

S-06.4: Katy Patras, Baylor College of Medicine - Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection

11:45

S-06.5: Sallie Fell, Tulane University - Evaluation of decidual vascularization across gestation in rhesus macaques with and without malaria in pregnancy

12:00 - 1:30

ASRI BUSINESS MEETING & LUNCH 

Chair: David Aronoff

ASRI President

Great River 1&4

Trainees only - RSVP required

Senior members will host discussions at tables with topics that are relatable and of interest to attendees at diverse stages in their careers.

1:30 - 3:30

S-07: TROPHOBLASTS

Chairs:  Tamara Tilburgs & Elizabeth Enninga

Great River 1

1:30

S-07.1: Thor Theunissen, Washington University St. Louis – Building human embryo and placenta models from naive stem cells

2:00

S-07.2: Lynda Harris, University of Nebraska Medical Center – From trophoblast biology to therapeutic interventions

2:30

S-07.3: Kaela Varberg, CMH - Leveraging human trophoblast stem cell models to study placental development

3:00

S-07.4: Sayaka Tsuda, Cincinnati Children's Hospital - Up-regulation of inhibitory molecules on extravillous trophoblasts contributes to immune protection in human pregnancies

3:15

S-07.5: Cynthia McMillen, University of Pittsburgh - Human trophoblasts and placenta explants are susceptible to Oropouche virus infection

1:30 - 3:30

S-08:  REPRODUCTIVE AGING AND IMMUNITY

Chairs:  Aihua Liao & Emilyn Alejandro

Great River 4

1:30

S-08.1: Michael Stout, Oklahoma Medical Research Foundation – Unraveling Cell-Type-Specific Mechanisms of Aging in the Murine Ovary

2:00

S-08.2: Aubrey Converse, Northwestern University - Failed Ovulatory Debris Clearance is Associated with Fibro-Inflammatory Responses in the Aging Ovary

2:30

S-08.3: Aihua Liao, Huazhong University of Science and Technology – Treg Cell Senescence in Female Reproductive Potential and Advanced Maternal Pregnancy

3:00

S-08.4: Rupesh Srivastava, All India Instutite of Medical Sciences (AIMS) - Therapeutic Targeting of Osteoclastogenic Th9 Cells : A Novel Approach to Combat Inflammatory Bone Loss in Postmenopausal Osteoporosis

3:15

S-08.5: Fernando Prado Ferreira, Sao Paulo Federal University - Exploring the Interplay Between Advanced Age and Altered Expression of Endometrial Markers: Implications for Relationships

3:30 - 3:45

COFFEE BREAK

Great River Court

3:45 – 5:45

S-09: COMPLEMENT AND ANTI-MICROBIAL FACTORS IN PREGNANCY AND PREGNANCY COMPLICATIONS

Chairs: Jean Regal & Belen Gimeno-Molina

Great River 1

3:45

S-09.1: Jean Regal, University of Minnesota - The Complement System and Preeclampsia - Preclinical Animal Studies

4:15

S-09.2: Richard Burwick, San Gabriel Valley Perinatal Medical Group, Pomona Valley Medical Center –Complement in Preeclampsia and HELLP Syndrome - Human and Translational Studies

4:45

S-09.3: Lynne Sykes, Imperial College of London – Modulating the cervicovaginal complement response as a therapeutic strategy for preterm birth prevention

5:15

S-09.4: Michelle Castillo, Medical College of Wisconsin - Neutrophils drive the formation of Bronchus-Associated Lymphoid Tissue (BALT) and progressive obstetric lung injury in mice with thrombophilia

5:30

S-09.5: Nina Prasanphanich, Cincinnati Children's Hospital - Drivers of antimicrobial functions of decidual natural killer cells in healthy term pregnancy

3:45 – 5:45

S-10: IMMUNOMETABOLISM

Chairs:  Steve McCartney & Eliza McColl

  Great River 4

3:45

S-10.1: Theresa Powell, University of Colorado – Maternal-Placental-Fetal Cross Communication: Metabolic Signals, Nutrients and Exosomes Determine Pregnancy Outcomes and Life-long Health

4:15

S-10.2: Catherine Thornton, Swansea University – Metabolic rewiring of the maternal immune response in pregnancy

4:45

S-10.3: Steve McCartney, University of Washington – Immunometabolism at the Maternal Fetal Interface

5:15

S-10.4: Tracy Her, University of Minnesota - Unlocking the complexity of gestational diabetes mellitus using a physiological model of multiparity  

5:30

S-10.5: Eliza McColl, Baylor College of Medicine - SARS-CoV-2 disrupts iron transport and activates ferroptosis in the human placenta

Free night / dinner on your own

AJRI Editorial Board Meeting (invitation only)

 7:00 - 4:00 

Registration Desk open

Great River Court

 7:00 - 8:00 

Continental Breakfast

Great River Court

PL04: PRESIDENT'S SESSION: 

Advancing Maternal-Child Health through Research: A Perspective from the March of Dimes

Emre Seli

March of Dimes

HERR AWARD LECTURE: 

The vaginal microbiome as a modifier of reproductive health outcomes

David MacIntyre

Imperial College London 

 9:30 -10:00 

COFFEE BREAK

Great River Court

10:00 - 12:00

S-11: FETAL/NEONATAL IMMUNITY

          Chairs: Nathan Schuldt & Tyler Rice

Great River 1

10:30

S-11.2: Amelie Collins, CCHMC – Maternal Inflammation Regulates Fetal Emergency Myelopoiesis

11:00

S-11.3: Naomi McGovern, Cambridge University – Human Placental Macrophages and How They Fight Listeria Monocytogenes Infection

11:30

S-11.4: Tyler Rice, Yale University - Fetal and maternal immune cells in placental villi exhibit dynamic transcriptional responses to both gestational age and complications of pregnancy

11:45

S-11.5: Jacquelyn Lajiness, Indiana University - The Role of IL-9 Signaling in Immune-Mediated Preterm Birth

10:00 - 12:00

S-12: EV-SPECIFIC IMMUNE IMPACT ON REPRODUCTIVE TISSUES

          Chair: Priya Pantham

Great River 4

10:00

S-12.1: Priya Pantham, UCSD – Placental Extracellular Vesicles as Mediators of Renal Dysfunction in Preeclampsia

10:30

S-12.2:Laura Goetzl, UTHealth Houston - CNS Derived Extracellular Vesicles - Applications to the Perinatal Period

11:00

S-12.3:Lawrence Chamley, University of New Zealand - Placental extracellular vesicles, a therapeutic role in ovarian cancer?

11:30

S-12.4: Hanah Georges, Yale University - Viral dsRNA triggers fetal membrane-released extracellular vesicles to express elevated TLR7/TLR8-activating microRNAs which sequentially mediate tissue inflammation

11:45

S-12.5: Rafael Tomoya Michita, Baylor College of Medicine - Zika Virus NS1 Induces Tunneling Nanotubes for Vertical Transmission and Disrupts Placental Mitochondrial Function

12:00 PM - 1:30 PM

LW3: THE VIVIAN ACT AND CMV SCREENING IN MINNESOTA

Chairs: Sylvie Girard, Craig Bierl & Elizabeth Enninga

Panelists: Mark Schleiss, University of Minnesota, 

Leah Henrikson and Stephanie Steidl

Great River 2&3

1:30 - 3:30 

S-13: GLYCOIMMUNOLOGY OF PREGNANCY

          Chairs: Wendy Goodman & Petra Lothert

Great River 1

1:30

S-13.1: Brian Cobb, Case Western University – Pregnancy-Induced Changes in IgG Function

2:00

S-13.2: Hai-Bin Ruan, University of Minnesota – Perinatal lymphoid-myeloid balance established by bone marrow stromal O-GlcNAc glycosylation

2:30

S-13.3: Adrian Erlebacher, UCSF – Glycan Regulation of Fetomaternal Tolerance

3:00

S-13.4: Seung-Woo Yang, Kongkuk University, South Korea - Sialylated Immunoglobulin binding to DC-SIGN expressed Hofbauer cells induces its immune tolerable function in the placenta

3:15

S-13.5: Yosuke Ono, University of Yamanashi, Japan- Involvement of anti-β2-glycoprotein I /HLA-DR antibody in recurrent pregnancy loss and adverse obstetric outcomes

1:30 - 3:30 

S-14: THERAPEUTIC DEVELOPMENT - VACCINES AND ANTI-INFLAMMATORIES

          Chairs: Natasha Tilston-Lunel & Enrico Barrozo

Great River 4

1:30

S-14.1: Patrick Duffy, NIH – Vaccines for pregnancy malaria—progress and possibilities:

2:00

S-14.2: Kristin Adams Waldorf, University of Washington – Impact of an Interleukin-1 Receptor Antagonist on Preterm Labor and Bacterial Trafficking in a Pregnant Nonhuman Primate Model

2:30

S-14.3: Natasha Tilston-Lunel, Indiana University – Establishing a Murine Model to Investigate Vertical Transmission of Oropouche Virus

3:00

S-14.4: Jing Luo, Huazhong University of Science and Technology - Macrophage membrane-encapsulated dydrogesterone nanocrystal delivery system: a new strategy for improving the progression of adenomyosis via inhibiting inflammation in uterus

3:15

S-14.5: Austin Hertel, University of Pittsburgh - Protecting mothers and neonates from Rift Valley Fever: RVFV-delNSs/NSm vaccine prevents vertical transmission and neonatal mortality following maternal vaccination

7:00 - 11:00 

ASRI "LAND O'LAKES" DINNER & AWARDS CEREMONY

Uff Da! Celebrate all that is Minnesota - the "Land of 10,000 Lakes" - with this fun evening honoring our scientists and embracing the rich heritage of this state.

After dinner & awards, you betcha we'll open up the dance floor! 

Great River 2&3