The American Society forReproductive Immunology |

| 1:00 - 2:30 |
FCRI Exams |
Meeting Room 1 | |
| 2:30 - 3:30 | FCRI Board Meeting | Meeting Room 1 | |
| 2:30 - 3:30 | ECI Committee Meeting | Meeting Room 2 | |
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3:00 - 6:30 |
Registration Desk open |
CBC 2nd Level Landing |
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| 4:00 - 6:15 |
TW |
Trainee Workshop: Next Generation Tools for Next Generation Scientists Solving Complex Problems Chairs: Eliza McColl, Tyler Rice, Amabebe Emmanuel, Hanna Georges |
Meeting Room 1 |
| 4:00 | Mancy Tong, Yale University - Extracellular vesicle-mediated communication in pregnancy: Challenges and opportunities | ||
| 4:25 | Ourland Tantengco, UTMB - Extracellular Vesicles as Hidden Drivers of Pregnancy Inflammation: Insights from Organ-on-Chip Microphysiological Models | ||
| 4:50 | Jennifer Manuzak, Tulane University - Building the bridge: Using the nonhuman primate model to gain translational insight into maternal-fetal immunity | ||
| 5:15 | Blair Armistead, University of Washington/Seattle Children's Hospital - Making the most of milk: Overcoming challenges in studying breastmilk T cell biology | ||
| 5:40 | Panel Discussion | ||
| 4:30 - 6:00 |
ASRI Executive Council Meeting (ASRI Council & Committee Chairs only) |
Meeting Room 2 | |
| 6:30 - 8:30 | TN |
TRAINEE NETWORKING EVENT @ LexLive! Included for all Trainees (advance RSVP required; must wear name badge) |
LexLive |
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7:00 - 4:00 |
Registration Desk open |
CBC, 2nd Level Landing |
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7:00 - 8:00 |
Continental Breakfast |
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| 8:15 - 9:30 | PL1 |
PL01: CHAIR'S SESSION |
Meeting Rooms 1-2 |
| 8:15 | Welcome Remarks & Introduction | ||
| 8:30 | PL1.1 |
AJRI 2024 AWARD LECTURE: Revisiting the Utility of Interleukin-10 using New Approach Methods: Old Wine in a New Bottle
Ramkumar Menon, PhD University of Texas Medical Branch |
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9:00 |
PL1.2 |
2025 HERR AWARD LECTURE: The Placenta Lives On: Lasting Imprints of Inflammation on Mother and Child
Sylvie Girard Mayo Clinic |
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9:30 - 10:00 |
COFFEE BREAK |
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10:00 - 12:00 |
S-01 |
Infection during Pregnancy: Pathogenesis, Prevention, and Treatment
Chairs: Ilhem Messaoudi & Anna Powell |
Meeting Rms 1-2 |
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10:00 |
S-01.1 |
Sallie Permar, Cornell University - Ending Lifelong Disabilities with a CMV Vaccine |
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10:30 |
S-01.2 |
Rupak Shivakoti, Columbia University - Maternal Inflammation in HIV and TB infection |
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11:00 |
S-01.3 |
Tatyana Kushner, Weill Cornell Medicine - Updates and remaining frontiers on hepatitis B and hepatitis C management in pregnancy |
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11:30 |
S-01.4 |
Elisha Segrist, National Institute for General Medical Sciences - Microbiota-dependent IFN-L controls uterine and placental immunity |
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11:45 |
S-01.5 |
Samantha Ottinger, Baylor College of Medicine -Maternal urinary tract infection initiates preterm birth through placental T cell inflammation |
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10:00 - 12:00 |
S-02 |
Host-Microbiota Dynamics in Pregnancy and Early Life: From Molecular Mechanisms to Clinical Impact Chairs: David MacIntyre & Ryan Doster |
Meeting Room 3 |
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10:00 |
S-02.1 |
Omry Koren, Bar-Ilan University - The role of the gut microbiome in first 1000 days of life |
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10:30 |
S-02.2 | Tal Korem, Columbia University - The vaginal ecosystem and adverse pregnancy outcomes |
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11:00 |
S-02.3 | Seth Bloom, Massachusetts General Hospital - Mechanisms of Host-Microbiota Cross-Talk in the Female Reproductive Tract | |
| 11:30 | S-02.4 |
Emmanuel Amabebe, University of Texas Medical Branch at Galveston - Distinct vaginal microbiota and extracellular vesicles proteomic signatures reveal mechanistic links to preeclampsia |
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| 11:45 | S-02.5 |
Purna Shah, Boston University - Human Contraceptive Antibody Fab- and Fc-mediated functions are enhanced by sialidases from dysbiotic vaginal bacteria |
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12:00 - 1:30 |
LUNCH BREAK |
on your own
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1:30 - 3:30 |
S-03 |
A Shift Towards the Immunology of Endometriosis Chairs: Chandra Tayade & Katherine Burns |
Meeting Rms 1-2 |
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1:30 |
S-03.1 |
Semir Beyaz, Cold Spring Harbor Laboratory - Deconstructing Human Endometrium by Multi-omics and Organoid Mode |
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2:00 |
S-03.2 |
Elise Courtois, The Jackson Laboratory - Defining the Neuro-Immune Architecture of Endometriosis Lesions: Insights from Single-Cell and Spatial Omics |
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2:30 |
S-03.3 |
Katherine Burns, University of Cincinnati -Neutrophils as key effectors in the diagnosis and development of endometriosis |
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3:00 |
S-03.4 |
Tao Zhang, The Chinese University of Hong Kong - Targeting monocytic myeloid-derived suppressor cells: a novel mechanism for Pro-EGCG in inhibiting endometriosis progression |
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3:15 |
S-03.5 |
Winnie Kamau, Baylor College of Medicine - The Role of Microbiota-Derived Metabolites in the Endometriosis Pathophysiology |
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1:30 - 3:30 |
S-04 |
Congenital infections: Mechanisms, models, and maternal-Fetal Impact Chairs: Indira Mysorekar & Sallie Fell |
Meeting Room 3 |
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1:30 |
S-04.1 |
Stephanie Gaw, UCSF - Placental Macrophages, Malaria, and Fetal Growth |
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2:00 |
S-04.2 | Jean Lim, Icahn SOM at Mt. Sinai - Understanding Factors that Increase Susceptibility to Zika virus infection during pregnancy | |
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2:30 |
S-04.3 |
Nadia Roan, UCSF - Viral-specific T cell responses at the maternal-fetal interface |
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3:00 |
S-04.4 |
Eliza McColl, Baylor College of Medicine - First human trophoblast models enabling Treponema pallidum growth uncover shared pathways driving transplacental infection and pathogenesis in congenital syphilis |
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3:15 |
S-04.5 |
Nina Prasanphanich, Cincinnati Children's Hospital Medical Center - Granulysin expression by decidual natural killer cells signifies high antimicrobial activity without cytotoxicity |
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3:30 – 4:00 |
COFFEE BREAK |
Meeting Room Foyer |
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3:30 – 6:00 |
PS |
POSTER SESSION (All Posters) |
Meeting Rms 6-7 |
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4:00 – 5:00 |
POSTER JUDGING (Top Poster Finalists) |
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6:00 - 7:30 pm |
WELCOME RECEPTION (all attendees & registered guests)
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Free Night / Dinner on your own |
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7:00 - 4:00 |
Registration Desk open |
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7:00 - 8:00 |
Continental Breakfast |
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8:00 - 9:30 |
PL2 |
BYRNE FOUNDATION SESSION: From IgA to HIV: Fifty Years of Reproductive Immunology - An Homage to Charles Wira Chairs: Charu Kaushic & Chuck Wira |
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| 8:00 | PL2.1 | Charu Kaushic, Mc Master University - Understanding the interactions between sex hormones, microbiota and mucosal immunity to improve vaginal health: From Bench to Bedside | |
| 8:30 | PL2.2 |
Marta Rodriguez-Garcia, Wayne State University - From NETs to lymphoid aggregates: understanding mucosal immunity in the female reproductive tract |
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| 9:00 | PL2.3 | Mimi Ghosh, George Washington University - Biological Determinants of HIV Susceptibility: How Sex Hormones Shape Mucosal Immunity in at-Risk Women | |
| 9:30 | PL2.4 |
2025 CAROLYN COULAM AWARD LECTURE: Training for Two: Maternal immunity, HIV and the science of endurance
Anna Powell, PhD Johns Hopkins University |
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10:00 - 10:30 |
COFFEE BREAK |
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10:30 - 12:30 |
S-05 |
Choreoamnionitis: Inflammation at the Maternal-Fetal Interface and its Contribution to Adverse Pregnancy Outcomes Chairs: Jennifer Gaddy & David Aronoff |
Meeting Rooms 1-2 |
| 10:30 | S-05.1 | Teresa Chou, Northwestern University - Human placental membrane macrophages mount a global inflammatory response to in utero Group B Streptococcus infection | |
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11:00 |
S-05.2 | Cole McCutcheson, Duke University - Tiny Packages, Big Impact: How Group B Streptococcal Membrane Vesicles Promote Chorioamnionitis |
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11:30 |
S-05.3 | Morgan Collins, Michigan State University - Role of progesterone in vaginal immunity to Group B Streptococcus colonization during pregnancy |
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12:00 |
S-05.4 |
Justine Noel, NIH National Center for Advancing Translational Sciences (NCATS) - A human placenta barrier model for translational assessment of inflammatory and autoimmune stressors across gestation |
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| 12:15 | S-05.5 |
Sidong Wang, The University of Hong Kong - EVT-eNK Immune Crosstalk in Early Implantation: HLA-G as a Master Regulator of Uterine Immune Homeostasis |
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10:30 - 12:30 |
S-06 |
The Fallopian Tube Immune Microenvironment: Implications for Infertility, Ectopic Pregnancy, and Ovarian Cancer Chairs: Pooja Popli / Irina Burd |
Meeting Room 3 |
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10:30 |
S-06.1
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Ronny Drapkin, University of Pennsylvania - The Ovarian Pre-Cancer Atlas: Detecting and Intercepting Ovarian Cancer at Its Origin |
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| 11:00 | S-06.2 | Wipawee "Joy" Winuthayanon, University of Missouri - Classical progesterone action and immune cells in the oviduct during preimplantation embryo development | |
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11:30 |
S-06.3 | Dineo Khabele, Washington University of St. Louis -Macrophages in the Immune Microenvironment of Ovarian Cancer |
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12:00 |
S-06.4 |
Sarah Nelson, Southern Illinois University School of Medicine - Alteration of tryptophan catabolism in the endometrial tumor microenvironment |
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12:15 |
S-06.5 |
Khaliun Dashdeleg, Rosalind Franklin University of Medicine and Science - Immunotherapy Outcomes in Diminished Ovarian Reserve versus Normal Ovarian Reserve Patients with Recurrent Pregnancy Loss: A Single-Center Retrospective Study |
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12:30 - 2:00 |
ASRI BUSINESS MEETING & LUNCH
Chair: Indira Mysorekar, ASRI President |
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2:00 - 4:00 |
S-07 |
Decidual-immune crosstalk for successful reproductive outcomes Chairs: Mancy Tong & Laiba Jamshed |
Meeting Rooms 1-2 |
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2:00 |
S-07.1 |
Dorothy Sojka, Loyola University - Poor pregnancy outcomes in the absence of tissue-resident natural killer cells |
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2:30 |
S-07.2 |
Elizabeth Enninga, Mayo Clinic - Interactions between T cells and decidual stromal cells which promote chronic inflammation |
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3:00 |
S-07.3 |
TBD - Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage |
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3:30 |
S-07.4 |
Sonresa Ochoa-Vidales, University of Pennsylvania - Uterine natural killer cells require type I interferon to promote fetoplacental development |
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3:45 |
S-07.5 |
Laiba Jamshed Khan, Yale University - Regulation of Decidualization by Toll-Like Receptor Signaling in Recurrent Implantation Failure: Insights from Integrated Single-Cell and In Vitro Functional Analyses |
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2:00 - 4:00 |
S-08 |
Maternal Circulating Immunity and Vascular Stress in Preeclampsia: From Mechanisms to Biomarkers Chairs: Anna Borchers & Emmanuel Amabebe |
Meeting Room 3 |
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2:00 |
S-08.1 |
Lana McClements, University of Technology, Sydney - FK506 binding protein like (FKBPL) - a novel and critical angiogenesis-related mechanism and biomarker in preeclampsia |
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2:30 |
S-08.2 |
S. Ananth Karumanchi, Cedars Sinai - Vascular Mechanisms of Preeclampsia |
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3:00 |
S-08.3 |
Sarosh Rana, University of Chicago - TBD |
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3:30 |
S-08.4 |
Yi Cao, Yale University - Placental villi T cells from preterm birth impair trophoblast organoid growth and functions |
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3:45 |
S-08.5 |
Dorien Feyaerts, Stanford University - Temporal and spatial immune monitoring of preeclampsia |
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4:00 - 4:30 |
COFFEE BREAK |
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4:30 - 6:30 |
S-09
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Breaking Barriers: Innovative Immunotherapies in Human Reproduction Chairs: Joanne Kwak-Kim & TBD |
Meeting Rooms 1-2 |
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4:30 |
S-09.1 |
Maria Salazar Garcia, Rush University - Immune Pathways in Endometriosis: Emerging Targets and Future Immunotherapies |
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5:00 |
S-09.2 |
Thanh Luu, Rosalind Franklin University - The endometrial environment and reproductive failures |
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5:30 |
S-09.3 |
TBD |
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6:00 |
S-09.4 |
Olivia Palmer, Dartmouth College - Sex hormones orchestrate transcriptional, metabolic, and functional programs in human macrophages |
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6:15 |
S-09.5 |
Lauren Stafford, Case Western Reserve University - Intranasal maternal influenza vaccination drives milk antibody responses through a respiratory–mammary axis in ferrets |
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4:30 - 6:30 |
S-10 |
Myeloid Cells in Genital Inflammation, Immune Protection and Reproductioneloids Chairs: Marta Rodriguez-Garcia & Mimi Ghosh |
Meeting Room 3 |
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4:30 |
S-10.1 |
Thomas Murooka, University of Manitoba - Caught in the NET: how non-optimal vaginal microbiome drive HIV susceptibility |
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5:00 |
S-10.2 |
Lucia Vojtech, University of Washington - Semen induces unique tolerogenic phenotypes in vaginal dendritic cells |
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5:30 |
S-10.3 | Jiahui "Candy" Ding, Wayne State University - Maternal Viral Infection Shapes Offspring Neutrophil Immunity and Infection Responses in a Sex-Specific Manner |
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6:00 |
S-10.4 |
Savannah Schick, Wayne State University - Regulation of placental inflammasome by A20 during pregnancy |
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6:15 |
S-10.5 |
Yonju Kim, Rosalind Franklin University - Dose-Dependent Effects of Sex Steroid Hormones on Cytokine Production by Human Peripheral Blood Mononuclear Cells |
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Free night / dinner on your own |
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| 7:00 - 9:00 |
AJRI Editorial Board Meeting (invitation only) |
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7:00 - 4:00 |
Registration Desk open |
CBC Foyer |
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7:00 - 8:00 |
Continental Breakfast |
Meeting Room Foyer |
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| 8:00 - 9:30 |
PL03 |
GUSDON AWARD SESSION Chairs: Rama Kommagani & Liza Konnikova |
Meeting Rooms 1-2 |
| 8:00 | G-01 |
J. Alejandra Rodriguez, Purdue University - Granzyme A Regulates Uterine Immune-Endocrine Homeostasis in the Female Reproductive Tract |
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| 8:15 | G-02 |
Sophia Chioma Chima, University of Washington - Gestational age-dependent innate immune responses to congenital viral infections in a nonhuman primate, ex vivo microculture model |
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8:30 |
G-03 |
Bokani Nleya, University of Alabama at Birmingham - Susceptibility of Cervical Mucosal Tissue from Cisgender Women vs. Transgender Men to ex vivo HIV-1 Infection |
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| 8:45 | G-04 |
Tracy Her, University of Minnesota - Placental macrophage and glycogen trophoblast dysregulation underlie sex-specific effects of maternal hyperinsulinemia, independent of obesity |
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| 9:00 | G-05 |
Melissa Cook, University of Pittsburgh - Collective loss of type 17 cytokines leads to estrogen-independent susceptibility to vulvovaginal candidiasis |
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| 9:15 | G-06 |
Petra Lothert, Mayo Clinic - Interferon-Producing Cytotoxic T Cells Shape Placental Antigen Presentation in Villitis of Unknown Etiology |
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9:30 -10:00 |
COFFEE BREAK |
CBC Foyer |
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10:00 - 12:00 |
S-11 |
Gynecological Cancers and Anti-Tumor Immunity Chairs: Andrea Braundmeier-Fleming & TBD |
Meeting Rooms 1-2 |
| 10:00 | S-11.1 | Andrea Braundmeier-Fleming, Southern Illinois University - Use of Microbial and Immune Profiling to Advance Ovarian Cancer Detection and Treatment | |
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10:30 |
S-11.2 |
Animesh Barua, University of Wisconsin, Milwaukee - Induction of ADAM10 protease by STAT3 in ovarian cancer prevents anti-tumor functions of NK cells and its inhibition |
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11:00 |
S-11.3 |
Sameer Sharma, Northwest Cancer Center - Tumor-induced changes in macrophage phenotype favors metastasis of ovarian cancer and its prevention |
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11:30 |
S-11.4 |
Ana Laura Schafir, IQUIBICEN UBA-CONICET - Endometrial Stromal ER Stress Transmission Reshapes Dendritic Cell Phenotype and Alters Trophoblast Behavior through IRE1α Signaling |
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11:45 |
S-11.5 |
Ying Lin, Brown University - Human ectocervical organoids as a model to study host-microbial interactions in female reproductive mucosa |
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10:00 - 12:00 |
S-12 |
Pre- and Postnatal Immune Programming of Breastmilk: Impact of Breastfeeding on Infants Chairs: Brett Vahkal & Tyler Rice |
Meeting Room 3 |
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10:00 |
S-12.1 | Maria Carmen Collado, Polytechnic University of Valencia - Feeding Microbes: The role of breastfeeding in early-life microbial and immune development | |
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10:30 |
S-12.2 | Timothy Hand, University of Pittsburgh - Measuring the Assembly of the Neonatal Microbiota, One Cell at a Time |
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11:00 |
S-12.3 | Liat Shenhav, New York University - Human Milk as a Microbial Pacemaker |
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11:30 |
S-12.4 |
Delphine Malherbe, University of Kentucky - Neonatal outcomes and immune reprogramming induced by prenatal opioid and hepatitis C exposure |
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11:45 |
S-12.5 |
Victoria Federico, Vanderbilt University - Human Milk Oligosaccharides Meet Magnetic Bead Electrochemical Biosensors: Investigating Inflammatory Cytokines Implicated in Preterm Birth |
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12:00 - 1:30 |
Free Time / Lunch on your own |
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1:30 - 3:30 |
S-13 |
Advancing the understanding of fetal development and neonatal outcomes using multi-omics platforms Chairs: Ina Stelzer & Kerri St. Denis |
Meeting Rooms 1-2 |
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1:30 |
S-13.1 |
Ai Ing Lim, Princeton University - Maternal-Offspring Immune Partnerships |
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2:00 |
S-13.2 |
Serena Banu Gumusoglu, University of Iowa - The role of extracellular vesicles in offspring neuroimmune development |
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2:30 |
S-13.3 | Jelmer Prins, University Medical Center Groningen - Pre and postnatal factors influencing immune development in early life in preterms |
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3:00 |
S-13.4 |
Hanah Georges, Yale School of Medicine - LPS-stimulated human fetal membrane-derived small extracellular vesicles express elevated miR-21a and induce fetal lung cell inflammation through TLR7 and TLR8 |
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3:15 |
S-13.5 |
Kalida Gawon, Yale School of Medicine - Early-life mucosal T cells direct stem cell renewal and secretory lineage commitment in the small intestine |
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1:30 - 3:30 |
S-14 |
Beyond the Mouse: Comparative Insights into Reproductive Immunology Using Non-Traditional Animal Models Chairs: Jennifer Manuzak & Katherine Halloran |
Meeting Room 3 |
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1:30 |
S-14.1 | Hossam El-Sheikh Ali, University of Kentucky - Equine Ascending Placentitis: A Promising Translational Model for Human Chorioamnionitis |
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2:00 |
S-14.2 |
Melissa Bauman, UC Davis - Primate models as a translational tool for understanding prenatal origins of neurodevelopmental disabilities associated with maternal infection |
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2:30 |
S-14.3 |
Alex Pasternak, University of Kentucky - Understanding the response to maternal and fetal infection in the pig |
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3:00 |
S-14.4 |
Rebecca Hutchinson, University of Kentucky - Transcriptomic profiling identifies key regulators of myometrial activation in equine placentitis |
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3:15 |
S-14.5 |
Jeremia Coish, Tulane National Biomedical Research Center - Spatial transcriptomic profiling of decidua in primary RhCMV infection reveals a Th2-skewed and checkpoint-enriched microenvironment that supports extracellular/perivascuar remodeling |
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| 3:30 - 6:30 | Free Time / on your own | ||
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6:30 - 11:00 |
ASRI DINNER & AWARDS CEREMONY: "RUN FOR THE ROSES"
($85 attendees / $125 guests) |
meet in lobby |
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7:30 -12:00 |
Registration Desk open |
CBC Foyer |
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7:30 - 8:30 |
Continental Breakfast |
CBC Foyer |
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8:30 - 9:30 |
PL04 |
PRESIDENTIAL SESSION |
Meeting Rooms 1-2 |
| 8:00 | PL04.1 |
KEYNOTE LECTURE: Systems Immunology of the Maternal-Infant Dyad
John Tsang, PhD Yale University |
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9:30 - 10:30 |
PL04.1 |
PANEL DISCUSSION: Harnessing Discoveries & Opportunities Chairs: Indira Mysorekar & TBD Panel Discussion |
Meeting Rooms 1-2 |
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10:30-11:00 |
Closing & Coffee |
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*The HIiton offers a complimentary airport shuttle (limited capacity) - RSVP in advance to reserve a seat by contacting the hotel directly. The shuttle typically runs every 30 minutes on the hour and half hour. The hotel is a 15 minute drive to the airport; plan to arrive at least 1 hour before your flight departs.